Table 7 Pathways significantly associated with top candidate genes by ToppFun.
Pathway ID/name | Description | Source | p-value | Terms in query | Terms in genome |
|---|---|---|---|---|---|
hsa04080 | Neuroactive ligand-receptor interaction | KEGG pathway | 5.36 × 10-5 | 10 | 256 |
REACTOME_GPCR_LIGAND_BINDING | Genes involved in GPCR ligand binding | MSigDB: C2.cp - Reactome | 2.66 × 10-3 | 10 | 392 |
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors | MSigDB: C2.cp - Reactome | 4.36 × 10-3 | 7 | 173 |
REACTOME_DOWNSTREAM_EVENTS_IN_GPCR_SIGNALING | Genes involved in Downstream events in GPCR signaling | MSigDB: C2.cp - Reactome | 8.63 × 10-3 | 10 | 448 |
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) | MSigDB: C2.cp - Reactome | 1.62 × 10-2 | 8 | 292 |
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signaling events | MSigDB: C2.cp - Reactome | 2.78 × 10-2 | 6 | 157 |