Figure 3From: Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencingDNA methylation levels of different genomic elements in colorectal carcinoma cell lines HCT116 and DKO. Box plots based on the distribution of DNA methylation levels measured by double-enzyme RRBS are shown; differential methylation was tested by the chi-square test (***, P<0.001).Back to article page