Figure 1

Phenotype data. A) Colonic worm burden across the F2 population with parental strains. B) Serum IgG1:IgG2a ratio was significantly different between resistant (0 worms) and susceptible (>0 worms) groups. C) Normal colonic histology in resistant mouse with predominant serum IgG1 (x100 magnification. H&E stain. Bar = 200μm). Histological mucosal and submucosal colonic inflammation, with crypt hyperplasia and elongation, seen in the vicinity of (D), and away from (E) T. muris colonic worms (arrow). F) Serum IgG1:IgG2a ratio, and G) colonic worm count correlate with histological inflammatory features.