Genetic analysis of the Trichuris muris-induced model of colitis reveals QTL overlap and a novel gene cluster for establishing colonic inflammation

Table 1 Summary of Trichuris muris QTL ( Tm ) found across the genome

T. Muris QTL	Murine chrom	Left marker	Right marker	LOD^a	Trait	Dominance	Gene no. within QTL (Ensembl)	AKR vs BALB/c genes with SNPs
Tm1	1	D1Mit33	D1Mit36	2.39	Serum IgG’s Worm count	−8.3	90	68
Tm3	3	D3Mit156 92.4Mbp	D3Mit79 118.3Mbp	2.80	Serum IgG’s Worm count	8.4	342	270
Tm4	4	D4Mit166	D4Mit12	3.23	Serum IgG’s	−5.3	311	289
Tm10	10	D10Mit14	D10Mit35	4.10	Worm count	-	27	24
Tm11	11	D11Mit99	D11Mit61	4.14	Serum IgG’s Worm count	−0.3	265	182
Tm12	12	D12Mit285	D12Mit201	4.7	Serum IgG’s Worm count	−10.7	95	75
Tm17	17	D17Mit175	D17Mit176	8.04	Serum IgG’s Worm count	−5.7	287	251

^aFor non-parametric traits, Kruskal Wallis values were converted to LOD according to published methods [13].

ISSN: 1471-2164