Genetic analysis of the Trichuris muris-induced model of colitis reveals QTL overlap and a novel gene cluster for establishing colonic inflammation

Table 2 Significantly expressed Tm3 genes possessing strain-specific SNPs and a designated biological (KEGG) pathway

Gene	KEGG designated pathway	SNP no.	Gene	KEGG designated pathway	SNP no.
Vav3	Chemokine signalling pathway	2047	Fcgr1	Fc gamma R-mediated phagocytosis	18
	Fc gamma R-mediated phagocytosis			Hematopoietic cell lineage
	Focal adhesion			Leishmaniasis
	Leukocyte transendothelial migration			Phagosome
	T cell receptor signalling pathway			Systemic lupus erythematosus
	B cell receptor signalling pathway		Prpf38b	Spliceosome	9
	Regulation of actin cytoskeleton
Hmgcs2	Butanoate metabolism	134	Vcam1	Cell adhesion moleculaes (CAMs)	8
	Metabolic pathways			Leukocyte transendothelial migration
	Synthesis and degradation of ketone			Malaria
	Terpenoid backbone biosynthesis		Cdc14a	Cell cycle	7
	Valine, leuckine and isoleucine degradation
Ctss	Antigen processing and presentation	120	Dbt	Metabolic pathways	2
	Lysosome			Valine, leucine and isoleucine degradation
	Phagosome
Ap4b1	Lysosome	92	Gstm7	Drug metabolism – cytochrome P450	2
Rorc	Circadian rhythm	76		Glutathione metabolism
				Metabolism of xenobiotics by cytochrome p450
Gstm3	Drug metabolism – cytochrome P450	73	Hsd3b6	Metabolic pathways	2
	Glutathione metabolism			Steroid hormone biosynthesis
	Metabolism of xenobiotcis by cytochrome P450
Dpyd	Beta-Alanin metabolism	24	Fmo5	Drug metabolism – cytochrome p450	1
	Drug metabolism – other enzymes
	Metabolic pathways		Gstm6	Drug metabolism – cytochrome p450	1
	Pantothenate and CoA biosynthesis
	Pyrimidine metabolism		Hist2h2be	Systemic lupus erythematosus	1

ISSN: 1471-2164