Figure 1

Effect of sucrose on survival of RNAi candidates. Ranked estimates and confidence intervals (orange/purple: 95%, gray: Bonferroni-adjusted, N = 113) for the ln(OR) of knockdown vs. non-knockdown sibling pupariation on 1.0 M sucrose vs. 0.15 M sucrose. For each human gene, the cross with the most dramatic effect is shown; crosses that were lethal independent of dietary sucrose are omitted. Bars are labeled with the names of the human orthologs corresponding to each RNAi line; the names of the RNAi lines themselves are in Additional file 1: Table S1. We considered crosses whose 95% confidence intervals exclude zero as hits, and we considered crosses whose Bonferroni-adjusted confidence intervals exclude zero as strong hits. In a few cases, a gene was a hit in both directions; in such cases, both crosses are shown and the gene name is marked with an asterisk. More complete details are in Additional file 1: Tables S1 and S2.