Table 2 GO enrichment analysis of eQTL modules/hotspots found by GFlasso
Group | eQTL Hotspot | eQTL module size | GO Category | p-value | GO size (overlap) | GO Annotation [9] |
|---|---|---|---|---|---|---|
Ribi Group | *II:560000 | 722 | nucleolus | 1.4e-81 | 224 (148) | Cytoplasm organization and biogenesis |
ribosome biogenesis | 5.4e-62 | 311 (156) | ||||
V:350000 | 618 | ribosome biogenesis | 7.0e-104 | 311 (184) | Â | |
nucleolus | 5.5e-89 | 224 (129) | ||||
V:420000 | 405 | nucleolus | 8.0e-80 | 224 (118) | Â | |
Ribosome biogenesis | 6.8e-66 | 311 (124) | ||||
VII:50000 | 350 | nucleolus | 7.6e-97 | 224 (124) | Â | |
| Â | Â | Â | ribosome biogenesis | 5.6e-83 | 311 (131) | Â |
Telomere Group | IV:150000 | 46 | cellular component unknown | 6.1e-21 | 683 (33) | Â |
helicase activity | 1.8e-17 | 80 (15) | ||||
X:20000 | 48 | cellular component unknown | 1.6e-22 | 683 (35) | Â | |
helicase activity | 1.4e-15 | 80 (14) | ||||
XII:780000 | 44 | helicase activity | 8.3e-10 | 80 (15) | Â | |
cellular component unknown | 1.2e-13 | 683 (26) | ||||
*XII:1070000 | 54 | helicase activity | 9.3e-19 | 80 (15) | none | |
| Â | Â | Â | cellular component unknown | 1.1e-16 | 683 (27) | Â |
Retrotransposon Group | V:460000 | 42 | none | - | - | Â |
*VIII:110000 | 147 | conjugation site of polarized growth | 1.6e-11 | 119 (20) | conjugation, RNA binding | |
7.6e-6 | 211 (18) | |||||
| Â | XV:90000 | 85 | none | - | - | Â |
Other eQTL modules | *II:380000 | 106 | none | - | - | Â |
*III:100000 | 168 | cell. amino acid derivative proc | 6.3e-31 | 215 (55) | Organic acid metabolism | |
transferase activity | 2.6e-7 | 623 (51) | ||||
*III:200000 | 62 | conjugation | 5.1e-7 | 119 (10) | Response to chemical stimulus | |
response to chem stimulus | 4.3e-6 | 400 (16) | ||||
*V:110000 | 45 | carbohydrate met. process | 1.2e-4 | 249 (9) | Â | |
cell. aromatic comp. met proc | 1.5e-4 | 65 (5) | ||||
XII:610000 | 53 | none | - | - | Â | |
*XII:680000 | 185 | lipid metabolic process | 1.3e-14 | 249 (36) | Lipid metabolism, ER | |
ER | 3.9e-10 | 350 (36) | ||||
*XIII:70000 | 76 | cell. amino acid derivative proc | 1.2e-4 | 215 (11) | Â | |
*XIV:450000 | 448 | translation structural molecule activity | 2.3e-28 | 373 (97) | Protein biosynthesis, intracellular transport | |
1.4e-15 | 325 (7) | |||||
XIV:550000 | 45 | none | - | - | Â | |
*XV:180000 | 406 | carbohydrate met. process | 3.5e-5 | 249 (36) | Gen of precursor met & energy | |
protein modification process | 4.8e-4 | 544 (21) | ||||
*XV:590000 | 76 | gen of precursor met. & energy | 2.6e-35 | 168 (42) | Gen of precursor met & energy | |
| Â | Â | Â | mitochondrial envelope | 3.8e-20 | 82 (37) | Â |