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Table 1 Characterization of editing prediction pipeline

From: Prediction of constitutive A-to-I editing sites from human transcriptomes in the absence of genomic sequences

A

 

# of all m.m. in Alu

# of A-to-I in Alu

A-to-I ration in all m.m.

STEP2: w/o PSS cutoff

95,187

57,502

60.41%

STEP3: PSS cutoff

8,721

7,266

83.32%

STEP4: in editing box

1,995

1,995

100%

B

 

Alu

Non- Alu repetitive

Non-repetitive

A-to-I

Editing boxes (sites)

238 (1995)

7 (61)

21 (189)

Ave. length (nt)

~108 nt

~86 nt

~71 nt

 

Ave. conversion rate of As to Is

~31%

~40%

~51%

A-to-C

0

0

2 [14]

T-to-G

0

0

1 [6]

A-to-T

0

0

0

T-to-A

0

0

0

C-to-A

0

1 [6]

1 [5]*

G-to-T

0

0

1 [5]

C-to-G

0

0

0

G-to-C

0

0

1 [5]*

C-to-T

0

0

1 [5]

G-to-A

0

0

1 [6]*

C

 

in IR AIu s

within 1 kb to IR AIu s

> 1 kb to IR AIu s

A-to-I editing boxes (sites)

208 (1763)

36 (310)

24 (172)

  1. (A) The enrichment of A-to-I conversion in Alu elements after each step of our computational flow. (B) Editing boxes/sites distribution in Alu, non-Alu repetitive and non-repetitive regions. Asterisk indicated non A-to-Gs (noncanonical editing) sites are validated to be false positives. (C) Editing boxes/sites distribution in IRAlus, within 1 kb to IRAlus and over 1 kb to IRAlus.