Figure 1
From: TRACER: a resource to study the regulatory architecture of the mouse genome
Genome organisation and TRACER. (A) Schematic representation of a genomic locus, with the different elements that control gene expression, and the specialized databases dedicated to their description (see Websites). The TRACER database displays information from a regulatory sensor that detects the regulatory influences active at its insertion site, outlining the characteristics and extent of genomic regulatory landscapes. (B) The GROMIT strategy. A transposon that contains the regulatory sensor can be remobilised in vivo from its start site by a transposase transgene (not shown) active only in the male germline [2]. The genomic position of the new insertions and the associated expression pattern defined by LacZ staining in mouse embryos is displayed in the TRACER database.