Figure 1From: Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genesMultiple sequence alignment of periaxin. The multiple sequence alignment of periaxin is displayed. The nuclear localization signal of periaxin (amino acids 118–196) comprises 3 highly basic sub-domains. The p.R167C mutation is located in the second sub-domain (amino acid sequence KFSRLRRGLKAEAVK).Back to article page