Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes

Table 6 Novel deleterious mutations specific to SAMP6/TaSlc

Location	Gene symbol	Gene name	Nucleotide change (cDNA)	Amino acid change	SIFT score	Polyphen-2 score
Chr2:29947531	Zdhhc12	zinc finger, DHHC domain containing 12	c.381G>A	p.R112C	0	0.999
Chr2:31793494	Lamc3	laminin gamma 3	c.4202A>G	p.D1380G	0.05	0.399
Chr7:132719753	Il4ra	interleukin 4 receptor, alpha	c.1860delC	p.S540fs	N.A.	N.A.
Chr10:79474903	Abca7	ATP-binding cassette, sub-family A (ABC1), member 7	c.5477G>A	p.R1826H	0.01	0.108
Chr15:99998371	Dip2b	DIP2 disco-interacting protein 2 homolog B	c.1708G>A	p.A544T	0.05	0.17
Chr17:25257897	Ptx4	pentraxin 4	c.176A>T	p.R34S	0^*	0.999
Chr19:4153338	Coro1b	coronin, actin-binding protein 1B	c.1253C>T	p.R393W	0	0.998

^*The score is low confidence because the prediction was based on sequences too closely related.

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