Table 3 An ANOVA analysis of integrin pathway genes significantly differentially expressed between CAN/IFTA Banff 0 (no CAN/IFTA), Banff 1 (mild CAN/IFTA) and Banff 2,3 (moderate severe CAN/IFTA)
From: Genomic meta-analysis of growth factor and integrin pathways in chronic kidney transplant injury
Gene symbol | Description | Pairwise significance |
|---|---|---|
Integrin subunits | ||
ITGA1 | integrin, alpha 1 | (1, 2), (1, 3) |
ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | (1, 3) |
ITGA6 | integrin, alpha 6 | (1, 2), (1, 3), (2, 3) |
ITGA9 | integrin, alpha 9 | (1, 2), (1, 3) |
ITGAD | integrin, alpha D | (2, 1), (3, 1) |
ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | (1, 2), (1, 3) |
ITGAV | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | (1, 2), (1, 3) |
ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, ) | (1, 2), (1, 3), (2, 3) |
ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | (1, 3) |
ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | (1, 3) |
ITGB5 | integrin, beta 5 | (1, 2), (1, 3) |
ITGB6 | integrin, beta 6 | (1, 2), (1, 3), (2, 3) |
ITGB8 | integrin, beta 8 | (1, 2), (1, 3) |
Integrin signaling pathway molecules associated with all grades of CAN | ||
PTEN | phosphatase and tensin homolog | (1, 2), (1, 3), (2, 3) |
PTENP1 | phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1 | (1, 2), (1, 3), (2, 3) |
Integrin signaling pathway molecules associated with mild and moderate CAN but cannot distinguish mild from moderate CAN | ||
ACTB | actin, beta | (1, 2), (1, 3) |
ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | (1, 2), (1, 3) |
ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | (1, 2), (1, 3) |
ACTR3B | ARP3 actin-related protein 3 homolog B (yeast) | (1, 2), (1, 3) |
ARF4 | ADP-ribosylation factor 4 | (1, 2), (1, 3) |
ARF6 | ADP-ribosylation factor 6 | (1, 2), (1, 3) |
ARPC1A | actin related protein 2/3 complex, subunit 1A, 41Â kDa | (1, 2), (1, 3) |
ARPC2 | actin related protein 2/3 complex, subunit 2, 34Â kDa | (1, 2), (1, 3) |
ARPC4 | actin related protein 2/3 complex, subunit 4, 20Â kDa | (2, 1), (3, 1) |
ARPC5 | actin related protein 2/3 complex, subunit 5, 16Â kDa | (1, 2), (1, 3) |
CAPN10 | calpain 10 | (2, 1), (3, 1) |
CAPN6 | calpain 6 | (2, 1), (3, 1) |
CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | (1, 2), (1, 3) |
GRB2 | growth factor receptor-bound protein 2 | (1, 2), (1, 3) |
KRAS | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | (1, 2), (1, 3) |
MYLK | myosin, light chain kinase | (1, 2), (1, 3) |
NRAS | neuroblastoma RAS viral (v-ras) oncogene homolog | (1, 2), (1, 3) |
PAK2 | p21 (CDKN1A)-activated kinase 2 | (1, 2), (1, 3) |
PAK7 | p21(CDKN1A)-activated kinase 7 | (2, 1), (3, 1) |
PIK3C2A | phosphoinositide-3-kinase, class 2, alpha polypeptide | (1, 2), (1, 3) |
PIK3C3 | phosphoinositide-3-kinase, class 3 | (1, 2), (1, 3) |
PIK3CA | phosphoinositide-3-kinase, catalytic, alpha polypeptide | (1, 2), (1, 3) |
PIK3CB | phosphoinositide-3-kinase, catalytic, beta polypeptide | (1, 2), (1, 3) |
PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | (1, 2), (1, 3) |
PPP1CB | protein phosphatase 1, catalytic subunit, beta isoform | (1, 2), (1, 3) |
PPP1CC | protein phosphatase 1, catalytic subunit, gamma isoform | (1, 2), (1, 3) |
PPP1R12A | protein phosphatase 1, regulatory (inhibitor) subunit 12A | (1, 2), (1, 3) |
ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | (1, 2), (1, 3) |
RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | (1, 2), (1, 3) |
SOS2 | son of sevenless homolog 2 (Drosophila) | (2, 1), (3, 1) |
TLN1 | talin 1 | (2, 1), (3, 1) |
TSPAN3 | tetraspanin 3 | (2, 1), (3, 1) |
TTN | titin | (2, 1), (3, 1) |
WIPF1 | WAS/WASL interacting protein family, member 1 | (1, 2), (1, 3) |
Integrin signaling pathway molecules specifically associated with moderate CAN | ||
ARF1 | ADP-ribosylation factor 1 | (1, 3) |
ARPC1B | actin related protein 2/3 complex, subunit 1B, 41Â kDa | (1, 3) |
ARPC5L | actin related protein 2/3 complex, subunit 5-like | (1, 3) |
CAPN7 | calpain 7 | (1, 3) |
GIT1 | G protein-coupled receptor kinase interactor 1 | (3, 1) |
ILK | integrin-linked kinase | (3, 1) |
ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | (1, 3) |
MLCK | MLCK protein | (3, 1) |
NCK2 | NCK adaptor protein 2 | (1, 3) |
PAK3 | p21 (CDKN1A)-activated kinase 3 | (1, 3) |
PIK3C2B | phosphoinositide-3-kinase, class 2, beta polypeptide | (1, 3) |
PIK3CD | phosphoinositide-3-kinase, catalytic, delta polypeptide | (1, 3) |
PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | (3, 1) |
PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | (1, 3) |
PPP1CA | protein phosphatase 1, catalytic subunit, alpha isoform | (1, 3) |
PPP1R12B | protein phosphatase 1, regulatory (inhibitor) subunit 12B | (3, 1) |
SOS1 | son of sevenless homolog 1 (Drosophila) | (3, 1) |
TSPAN4 | tetraspanin 4 | (1, 3) |
TSPAN5 | tetraspanin 5 | (1, 3) |
WASL | Wiskott-Aldrich syndrome-like | (3, 1) |