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Table 2 Genes that change differently on each side of the brain

From: Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response

Gene symbol

Entrez gene name

TBI-I fold change

TBI-C fold change

TBI-I/TBI-C ratio

Molecule type

Extracellular space

     

CSF1

colony stimulating factor 1 (macrophage)

3.70

2.09

1.77

cytokine

SPP1

secreted phosphoprotein 1

37.91

2.37

15.99

cytokine

ERAP1

endoplasmic reticulum aminopeptidase 1

5.84

3.05

1.92

peptidase

LCN2

lipocalin 2

71.82

3.90

18.44

transporter

TGFB2

transforming growth factor, beta 2

-4.00

-7.97

1.99

growth factor

SERPINA3

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

58.49

2.51

23.31

other

SERPING1

serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

5.81

2.03

2.86

other

TIMP1

TIMP metallopeptidase inhibitor 1

38.49

2.10

18.32

other

Plasma membrane

     

HLA-C

major histocompatibility complex, class I, C

9.30

3.66

2.54

transmembrane receptor

IGSF6

immunoglobulin superfamily, member 6

22.46

3.27

6.87

transmembrane receptor

IL13RA1

interleukin 13 receptor, alpha 1

4.53

2.27

1.99

transmembrane receptor

IL6ST

interleukin 6 signal transducer (gp130, oncostatin M receptor)

2.31

-3.28

7.57

transmembrane receptor

THBD

thrombomodulin

3.85

2.09

1.84

transmembrane receptor

KCNN4

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

3.09

-9.43

29.12

ion channel

EGFR

epidermal growth factor receptor

6.77

2.37

2.85

kinase

MGLL

monoglyceride lipase

-7.85

-18.15

2.31

enzyme

CD44

CD44 molecule (Indian blood group)

15.56

2.40

6.49

other

CLEC12A

C-type lectin domain family 12, member A

10.92

2.15

5.08

other

ITGA5

integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

4.83

2.68

1.80

other

SDC1

syndecan 1

13.68

2.57

5.33

other

Cytoplasm

     

LYN

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

6.94

3.78

1.84

kinase

PDE4B

phosphodiesterase 4B, cAMP-specific

5.60

2.36

2.37

enzyme

PTPN4

protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)

4.49

2.21

2.03

phosphatase

RASA1

RAS p21 protein activator (GTPase activating protein) 1

2.39

-2.11

5.04

transporter

HSPB1

heat shock 27 kDa protein 1

46.92

2.64

17.78

other

LCP1

lymphocyte cytosolic protein 1 (L-plastin)

6.08

2.80

2.17

other

LSP1

lymphocyte-specific protein 1

11.72

2.14

5.47

other

MYO1F

myosin IF

4.27

2.26

1.89

other

Nucleus

     

CBL

Cas-Br-M (murine) ecotropic retroviral transforming sequence

-3.40

-6.13

1.80

transcription regulator

CEBPD

CCAAT/enhancer binding protein (C/EBP), delta

11.27

2.04

5.53

transcription regulator

DEK

DEK oncogene

-3.01

-7.35

2.45

transcription regulator

STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

4.22

-3.77

15.91

transcription regulator

MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

28.18

7.33

3.85

enzyme

TOP2A

topoisomerase (DNA) II alpha 170 kDa

2.26

-2.41

5.44

enzyme

THRA

thyroid hormone receptor, alpha

-2.80

-11.52

4.12

ligand-dependent nuclear receptor

CCND1

cyclin D1

2.15

-2.03

4.36

other

Unknown

     

Slpi (includes others)

secretory leukocyte peptidase inhibitor

82.91

3.12

26.58

other

  1. TBI-I/TBI-C Ratio: Gene increased on both sides: ratio = (TBI-I)/(TBI-C); Gene decreased on both sides: ratio = 1/[(TBI-I)/(TBI-C)];
  2. Gene increased ipsilaterally and decreased contralaterally: ratio = (TBI-I)/-[1/(TBI-C)].