Table 5 List of putative STM 4661 CDS differentially regulated upon metal exposure
Label* | CDS description and putative function | Zn / Control | Cd / Control | |||
|---|---|---|---|---|---|---|
log2 Fold | FDR | log2 Fold | FDR | STM 2683 Homologs § | ||
Transport | ||||||
MESS4v1_360013 | Heavy metal-translocating P-type ATPase CadA | 5.32 | 1.53E-121 | 3.38 | 1.96E-171 | MESS2v1_740030 |
MESS4v1_360015 | conserved membrane protein of unknown function, putative CDF | 2.2 | 1.10E-29 | 0.88 | 1.12E-02 | Not found |
MESS4v1_520016 | ABC transporter, periplasmic binding protein, Zn import | −2.98 | 4.47E-96 | 4.19 | 9.71E-173 | MESS2v1_300037 |
MESS4v1_520017 | ABC transporter, permease protein, Zn import | −2.59 | 1.49E-33 | 3.28 | 9.43E-144 | MESS2v1_300038 |
MESS4v1_520018 | ABC transporter-related protein, Zn import | −2.61 | 1.01E-23 | 3.4 | 2.99E-59 | MESS2v1_300039 |
MESS4v1_670093 | Transporter protein of unknown function | −1.75 | 4.35E-06 | −1.44 | 3.69E-04 | MESS2v1_580019 |
MESS4v1_360039 | Zinc efflux system ZitB type | 1.11 | 2.35E-02 | 0.55 | 0.91 | MESS2v1_730268 MESS2v1_730269 fissed MESS2v1_p180001 (fragment) |
MESS4v1_610026 | Zinc, cobalt and lead efflux system ZntA | 1.77 | 1.07E-10 | −0.11 | 1 | MESS2v1_980073 |
MESS4v1_750116 | Aliphatic sulphonate ABC transporter | −1.02 | 1.35E-03 | −0.22 | 1 | Not found |
MESS4v1_240016 | Iron-hydroxamate transporter subunit ; ATP-binding component of ABC superfamily, FhuC | −0.81 | 0.25 | −1.3 | 7.08E-05 | MESS2v1_1320036 |
MESS4v1_360106 | ABC transporter, permease protein | 0.13 | 1 | 0.87 | 7.05E-03 | Not found |
MESS4v1_360107 | Transporter protein of unknown function | −0.28 | 1 | 0.8 | 3.68E-02 | Not found |
MESS4v1_670092 | Hemin transport protein HmuS | −0.63 | 0.66 | −0.8 | 6.41E-02 | MESS2v1_580018 |
Metal sequestration | ||||||
MESS4v1_360040 | Conserved and cytoplasmic protein of unknown function, contains 2 CPX Zn finger domains | 1.02 | 8.10E-02 | 0.54 | 1 | MESS2v1_730267, MESS2v1_p180003 |
MESS4v1_750294 | Xanthine dehydrogenase, Fe-S binding subunit XdhC, located in the cytoplasm | 0.86 | 5.42E-02 | 0.1 | 1 | Not found |
MESS4v1_280090 | Methyltransferase type 11, located in the cytoplasm | 0.2 | 1 | 1.05 | 1.03E-04 | MESS2v1_1480043 |
MESS4v1_520093 | Cyclic beta-glucan succinyl transferase OpgC, cytoplasmic membrane | 0.15 | 1 | 0.81 | 4.02E-02 | MESS2v1_310036 |
MESS4v1_360014 | Cytochrome c biogenesis protein, transmembrane region CcdA, putative, involved in reduction as Zn or Cd Sulfides | 4.07 | 4.31E-48 | 2.22 | 3.75E-31 | MESS2v1_740029 |
MESS4v1_360049 | Thiol:disulfide interchange protein CycY, putative, involved in reduction as Zn or Cd Sulfides, located in the periplasm | 1.12 | 1.07E-04 | 1.93 | 1.30E-24 | MESS2v1_730262 |
MESS4v1_360050 | Reduction as Zn or Cd Sulfides - putative thioredoxin protein | 1.18 | 8.54E-05 | 2.14 | 4.83E-29 | MESS2v1_730261 |
MESS4v1_360052 | Putative oxidoreductase protein involved in reduction as Zn or Cd Sulfides | 0.91 | 1.13E-02 | 1.86 | 9.13E-25 | MESS2v1_730259 |
MESS4v1_360053 | Conserved exported protein of unknown function, putative protein-disulfide isomerase | 0.82 | 4.09E-02 | 1.71 | 3.89E-22 | MESS2v1_730258 |
MESS4v1_360023 | Signal peptidase II. Aspartic peptidase. MEROPS family A08, located in cytoplasmic membrane | 1.85 | 1.54E-13 | 0.69 | 0.14 | MESS2v1_740019 |
MESS4v1_160007 | Peptide methionine sulfoxide reductase MsrA, putative, involved in reduction as Cd Sulfides | 8.49E-02 | 1 | 1.13 | 3.01E-04 | MESS2v1_1200004 |
MESS4v1_360103 | Glutathione S-transferas, putative, involved in reduction as Cd Sulfides | −0.26 | 1 | 0.98 | 1.81E-03 | Not found |
MESS4v1_310058 | Fe(3+)-binding periplasmic protein, FbpA | −0.87 | 9.42E-02 | −1.01 | 1.37E-03 | MESS2v1_1490012 |
MESS4v1_360047 | Conserved exported protein of unknown function, predicted metal-binding domain | 1.33 | 1.93E-07 | 2.27 | 1.93E-36 | MESS2v1_730264 |
MESS4v1_360048 | Conserved exported protein of unknown function, predicted metal-binding domain | 1.24 | 2.38E-06 | 2.19 | 8.73E-21 | MESS2v1_730263 |
MESS4v1_830506 | conserved exported protein of unknown function, putative metal-binding protein | 4.76E-02 | 1 | −0.9 | 5.15E-02 | MESS2v1_1530017 |
Regulation | ||||||
MESS4v1_580068 | ROK family protein | −0.84 | 3.37E-02 | −0.36 | 1 | MESS2v1_400012 |
Oxidoreduction | ||||||
MESS4v1_360054 | Cytochrome c-type biogenesis protein CdcA (fragment) | 0.92 | 2.06E-02 | 1.59 | 2.89E-18 | |
MESS4v1_360046 | Multicopper oxidase, type 3 | 1.24 | 4.42E-06 | 2.09 | 1.95E-19 | MESS2v1_730265 |
MESS4v1_750295 | Putative Medium FAD-binding subunit of molybdenum enzyme | 1.03 | 1.13E-02 | 0.29 | 1 | Not found |
MESS4v1_310027 | Aldo/keto reductase | −3.16E-02 | 1 | 0.74 | 7.75E-02 | MESS2v1_1480132 |
MESS4v1_340203 | Exported protein of unknown function, putative hydrolase | −3.91E-02 | 1 | 0.84 | 4.40E-02 | Not found |
MESS4v1_340204 | Conserved protein of unknown function, putative hydrolase | −5.32E-02 | 1 | 0.78 | 6.89E-02 | Not found |
MESS4v1_360100 | Putative dioxygenase | −0.25 | 1 | 0.98 | 4.02E-03 | Not found |
MESS4v1_360104 | 3-hydroxybutyryl-coA dehydrogenase | −0.22 | 1 | 0.8 | 4.28E-02 | Not found |
MESS4v1_820066 | Putative reductase | −0.1 | 1 | 0.88 | 1.07E-02 | MESS2v1_790060 |
MESS4v1_830086 | conserved exported protein of unknown function, putative succinate dehydrogenase/fumarate reductase, flavoprotein subunit | −0.21 | 1 | 2.18 | 2.63E-32 | MESS2v1_790137 |
Others | ||||||
MESS4v1_830271 | conserved protein of unknown function - N-acetyltransferase activity | −1.08 | 3.12E-04 | −0.47 | 1 | MESS2v1_1590041 |
MESS4v1_830272 | putative ornithine decarboxylase | −0.98 | 1.42E-02 | −0.62 | 0.32 | MESS2v1_1590040 |
MESS4v1_580067 | Tagatose-1,6-bisphosphate aldolase, located in the cytoplasm | −0.94 | 1.87E-02 | −0.4 | 1 | MESS2v1_400011 |
MESS4v1_360102 | Putative translation initiation inhibitor, yjgF family | −0.22 | 1 | 0.98 | 1.84E-03 | Not found |
Unclassified | ||||||
MESS4v1_360051 | protein of unknown function | 0.94 | 1.42E-02 | 1.8 | 3.06E-15 | Not found |
MESS4v1_280043 | conserved protein of unknown function | 0.89 | 3.06E-02 | 0.38 | 1 | Not found |
MESS4v1_330155 | conserved protein of unknown function | 0.83 | 8.89E-02 | 0.59 | 0.51 | Not found |
MESS4v1_430174 | conserved protein of unknown function | 0.88 | 2.49E-02 | 0.17 | 1 | MESS2v1_130027 |
MESS4v1_610025 | protein of unknown function | 1.04 | 2.09E-03 | −4.88E-02 | 1 | Not found |
MESS4v1_690015 | protein of unknown function | −1.64 | 1.71E-06 | 0.18 | 1 | Not found |
MESS4v1_720075 | protein of unknown function | 0.84 | 9.38E-02 | 0.43 | 1 | Not found |
MESS4v1_830036 | conserved exported protein of unknown function | −0.89 | 9.38E-02 | 0.32 | 1 | MESS2v1_790093 |
MESS4v1_110143 | conserved exported protein of unknown function | 2.75E-02 | 1 | 0.76 | 4.41E-02 | MESS2v1_1080055 |
MESS4v1_210104 | protein of unknown function | 0.46 | 1 | 0.76 | 6.06E-02 | Not found |
MESS4v1_230034 | protein of unknown function | −0.19 | 1 | 0.83 | 2.10E-02 | Not found |
MESS4v1_240036 | conserved exported protein of unknown function | 1.38E-03 | 1 | 0.75 | 6.82E-02 | Not found |
MESS4v1_360025 | protein of unknown function | 0.2 | 1 | 0.83 | 4.41E-02 | Not found |
MESS4v1_360101 | conserved protein of unknown function | −0.17 | 1 | 0.92 | 6.17E-03 | Not found |
MESS4v1_360109 | protein of unknown function | −0.12 | 1 | 1.03 | 1.37E-03 | Not found |
MESS4v1_490002 | conserved protein of unknown function | 0.12 | 1 | 0.78 | 6.89E-02 | MESS2v1_210010 |
MESS4v1_560009 | protein of unknown function | −7.77E-02 | 1 | 0.77 | 4.07E-02 | Not found |
MESS4v1_560010 | conserved exported protein of unknown function | −0.34 | 1 | 0.88 | 6.33E-03 | Not found |
MESS4v1_640142 | protein of unknown function | −0.57 | 0.69 | −0.82 | 3.68E-02 | Not found |
MESS4v1_680031 | protein of unknown function | −0.69 | 0.25 | −0.78 | 5.49E-02 | MESS2v1_590015 |
MESS4v1_710103 | conserved membrane protein of unknown function | −0.33 | 1 | 0.75 | 7.73E-02 | MESS2v1_650084 |
MESS4v1_750195 | conserved protein of unknown function | 0.32 | 1 | 0.81 | 2.31E-02 | MESS2v1_730184 |
MESS4v1_830287 | conserved protein of unknown function | −8.46E-02 | 1 | 0.76 | 6.14E-02 | Not found |
MESS4v1_110128 | conserved membrane protein of unknown function | −0.82 | 3.80E-02 | 0.56 | 0.63 | MESS2v1_1080036 |