Figure 6

Summary of the main histopathological and signalling events associated with AZM551248 administration. (A) Summary of the main events associated with MMPi administration. Histopathological findings are shown below the bar, whilst important changes in signalling pathways and miRNA expression are shown above the bar. (B) The cyclic relationship between miR-200 attenuation, transcription factor activation and TGFβ production. Up-regulated factors are denoted in red, down-regulated factors in green, whilst factors not directly measured in this study appear in white. Note: below the bar adapted from (Tugwood, Kelsall et al. 2012).