Comparative genomics of Salmonella entericaserovars Derby and Mbandaka, two prevalent serovars associated with different livestock species in the UK

Hayward, Matthew R; Jansen, Vincent AA; Woodward, Martin J

doi:10.1186/1471-2164-14-365

Table 1 Comparison of previously published genomic islands that distinguish between D1, D2, M1 and M2 in their gene complement

From: Comparative genomics of Salmonella entericaserovars Derby and Mbandaka, two prevalent serovars associated with different livestock species in the UK

SPI	Gene	D1	D2	M1	M2	Descriptor	Role in pathogenesis
CS54	ratA	-	+	+	+	Ribosome association toxin	No role in virulence [10]
	sivI	-	+	+	+	Outer membrane protein	No role in virulence [10]
	sivH	-	+	+	+	Invasin-like	Colonising peyers patch (Mouse) [10]
SPI-1	STM2901	-	-	+	+	Putative cytoplasmic protein	NI [40]
	STM2902	-	-	+	+	Putative cytoplasmic protein	NI [40]
	STM2903	-	-	+	+	Putative cytoplasmic protein	NI [40]
	SC2837	-	-	+	+	Hypothetical protein	NI [41]
	SC2838	-	-	+	+	Hypothetical protein	NI [41]
SPI-3	Pseudo	+	+	-	-	NI	NI [42]
	yadC	+	+	-	-	Fimbrial like protein	Stress response [42, 43]
	yadK	+	+	-	-	Fimbrial like protein	NI [42]
	yadL	+	+	-	-	Fimbrial like protein	NI [42]
	yadN	+	+	-	-	Fimbrial like protein	NI [42]
	htrE	+	+	-	-	Porin/ fimbrial assembly	High temperature resistance above 50°C [44]
	ecpD1	+	+	-	-	Pilin chaperone	Expressed with increasing temp above 22°C [44]
	ecpD2	+	+	-	-	Pilin chaperone	NI [42]
	Pseudo	+	+	-	-	NI	NI [42]
	rhuM	-	-	+	+	Cytoplasmic protein	Epithelial migration [45]
	STY4039	-	-	+	+	EnvR binding site	No role in virulence [46]
SPI-6	STY0296	+	+	-	-	Hypothetical protein	No role in virulence [46]
	STY0300 (sirA)	-	-	+	+	Transcription factor	Regulates expression of SPI1 and flagellum genes [47, 48]
	STY0301 (safC)	-	-	+	+	Outer membrane usher protein	Up regulated during intracellular replication [49]
	STY0302 (sciM)	-	-	+	+	Hemolysin-coregulated protein	NI [50]
	STY0303 (sciN)	-	-	+	+	Outer membrane lipoprotein	Need for Type VI secretion, biofilm formation [51]
	STY0307	-	-	+	+	Hypothetical protein	NI [50]
	STY0311	-	-	+	+	Mannosyl-glycoprotein	NI [50]
	STY0312	-	-	+	+	Hypothetical protein	NI [50]
	STY0319	-	-	+	+	Rhs-family protein	NI [50]
	STY0320	-	-	+	+	Putative cytoplasmic protein	NI [50]
	STY0321	-	-	+	+	Rhs1 protein	NI [50]
	STY0322	-	-	+	+	Hypothetical protein	NI [50]
	STY0323	-	-	+	+	Hypothetical protein	NI [50]
	safA	-	-	+	+	Fimibrial usher protein	No effect in virulence in mice [50, 52]
	Pseudo	-	-	+	+	NI	NI [46]
	safB	-	-	+	+	Periplasmic fimbrial chaperone protein	NI [46]
	safC	-	-	+	+	Outer membrane usher protein	Up regulated during intracellular replication [49]
	safD	-	-	+	+	Fimibrial usher protein	No effect in virulence in mice [52]
	STY0338	-	-	+	+	Periplasmic binding protein	NI [46, 50]
	Pseudo	-	-	+	+	NI	NI [46]
	sinR (pagN)	-	-	+	+	HTH transcription factor	No effect on virulence in mice [52, 53]
	NI	+	+	-	-	Rhs-family protein	NI
	NI	+	+	-	-	Rhs-family protein	NI
	NI	+	+	-	-	Phosphotriesterase	NI
	NI	+	+	-	-	Hypothetical protein	NI
	NI	+	+	-	-	Hypothetical protein	NI
	orf7 (Photorhabdus )	+	+	-	-	SinR-like, HTH transcription factor	NI [54]
	NI	+	+	-	-	Putative cytoplasmic protein	NI
	Pseudo	+	+	-	-	NI	NI
	Pseudo	+	+	-	-	NI	NI
	tcfA	+	+	-	-	Fimbrial protein	Increased expression with increased salinity, non virulence in INT-407 cells [55]
	tcfB	+	+	-	-	Fimbrial protein	Increased IgG-tcfB in patients with S. Typhi [56]
	tsaC	+	+	-	-	Fimbrial usher protein	No effect on adhesion to mice monolayers [57]
	tcfD	+	+	-	-	Fimbrial protein	NI [46]
	rnhA-dnaQ like	-	+	-	-	DNA polymerase 3 epsilon subunit ribonuclease H	NI [58]
	NI	-	+	-	-	Ribonuclease HI	NI
	gloB like	-	+	-	-	Hydroxyacylglutathione hydrolase	methylglyoxal degradation [46]
	mltD	-	+	-	-	Membrane-bound lytic murein transglycosylase D	Enchance virulence in Vibria anguillarum in zebrafish [59]
	NI	-	+	-	-	Methyltransferase UbiE/COQ5	Ubiquinone/ menaquinone biosynthesis [60]
	yafD	-	+	-	-	AP like endonuclease	Egg albumen resistance [7]
	NI	-	+	-	-	Putative drug efflux protein	NI
	NI	-	+	-	-	Hypothetical oxidoreductase	NI
	dkgB	-	+	-	-	2, 5 didehydrogluconate reductase B	Detoxing response to hyperosmotic solution [61]

SPI-6 distinguishes between S. Derby and S. Mbandaka strains. This island has also been extensively studied for a role in pathogenicity, and displays the largest amount of diversity in gene complement between S. Derby and S. Mbandaka. Interestingly the majority of the diversity in SPI gene complement between S. Derby and S. Mbandaka is additional genes in S. Derby isolates. NI signifies a lack of information on the ORF.

Back to article page

ISSN: 1471-2164

Contact us

Submission enquiries: bmcgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Genomics

Contact us