Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosis

Table 3 Validation of differentially expressed genes induced by bleomycin in lung tissues from both Fra-1 ^+/+ and Fra-1 ^∆/∆ mice

Affymetrix ID	Symbol	Gene title	Micro array	qRT-PCR
			KOT vs. WTT	KOT vs. WTT
			Fold change	Fold change
10487588	Il1a	Interleukin 1 alpha	1.87	3.40 ± 1.68*
10404389	Irf4	Interferon regulatory factor 4 (TF)	2.06	3.29 ± 1.08*
10597420	Ccr4	C-C chemokine receptor type 4	1.78	1.68 ± 0.18*
10545569	Reg3g	Regenerating islet-derived 3 gamma	4.61	6.89 ± 0.86*
10493831	S100a8	S100 calcium binding protein A8	−2.63	-3.57±1.70*

Data are presented as mean ± SD (n=3-4). *P<0.05, WTT vs KOT after bleomycin treatment.

ISSN: 1471-2164