Figure 5

Temporal expression profiles of early, delayed and late gastrin-induced genes. A subset of 181 markedly gastrin-induced genes with differing expression patterns in transient versus sustained mode were used to further characterize the temporal profiles. The data were extracted from the independent time series microarray experiment where sustained gastrin treated cells were harvested at 10 different time points between 15 min and 14 h. The samples from untreated control cells were harvested at time zero and throughout the time course (11 time points). These genes were grouped by time profiles and peak expression (based on mean fold induction of sustained versus untreated cells at the same time point, N=2) into 6 groups as illustrated in the heat map and panel a-f. See details in the main text.