Fine-tuning of microRNA-mediated repression of mRNA by splicing-regulated and highly repressive microRNA recognition element

Table 1 Highly splicing-regulated and highly repressive MRE regions in VEGF gene

Region	MRE region		microRNA^$	Range of repressive ratio (%)	Supported tissue from Fisher’s exact test
	Start	End			Cancer			Normal
	Start	End			Left side	Right side	Two tail	Left side	Right side	Two tail
1	1742	1782	hsa-miR-125a(15), hsa-miR-140(48)	15 ~ 48	Thyroid		Thyroid
2	1899	1921	hsa-miR-17-5p(35), hsa-miR-20a(39), hsa-miR-20b(41), hsa-miR-106a(21), hsa-miR-106b(35), has-miR-302d(30), hsa-miR-372(30), hsa-miR-520 g(19), hsa-miR-520 h(28)	19 ~ 41
3	1935	1955	hsa-miR-302d(40)	30		Ovary	Ovary
4	1992	2020	hsa-miR-15a(50), hsa-miR-16(51), hsa-miR-195(45)	45 ~ 51
5	2221	2243	hsa-miR-150(30)	30
6	2258	2282	hsa-miR-205(13)	13
7	2508	2554	hsa-miR-15b(25), hsa-miR-107(42), hsa-miR-147(39), hsa-miR-330(25)*	25 ~ 42		Salivary gland	Salivary gland		Liver	Liver
8	2567	2601	hsa-miR-34a(15), hsa-miR-34b(8), hsa-miR-373(22), hsa-miR-378(17)	8 ~ 22
9	3009	3029	hsa-miR-504(30)	30	Brain		Brain
10	3134	3160	hsa-miR-383(25)	25
11	3151	3172	hsa-miR-134(45)	45					Pancreatic islet	Pancreatic islet
12	3342	3362	hsa-miR-361(45)	45
13	3466	3486	hsa-miR-29b(18)	18

^$ Number in parentheses showed the experimental result of repressive ratio [48]. ^* The repressive ratio of hsa-miR-330 is inconsistent from original results.

ISSN: 1471-2164