Table 1 Potassium channels genes in the zebra finch genome
|  | Revised HUGO term ∆ | IUPHAR name (or other terms) | Ensembl model or chromosome location | Model! | Chicken ortholog ensembl gene ID* | dN/dS ratio vs. chicken ^Ω | Song system expression and marker | ESTIMA In SituClone genbank ID | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | HVC | LMAN | RA | X | Â | |||
6 TRANSMEMBRANE / 1 PORE K-CHANNELS | Â | Â | Â | Â | Â | Â | Â | Â | |||
KCNA Subunits - 6TM/1P (potassium voltage-gated channel subfamily a, shaker-related | |||||||||||
|  | KCNA1 | Kv1.1 | ENSTGUG00000011956 | Complete | ENSGALG00000017280 | 0.01 | +++ (↑↑) | +++ (↑↑) | + | +++ (↑) | FE737967 |
| Â | KCNA2 | Kv1.2 | ENSTGUG00000000897 | Partial | ENSGALG00000000442 | 0.00 | + | + | + | + | FE720882 |
| Â | KCNA3 | Kv1.3 | ENSTGUG00000000902 | Partial | ENSGALG00000000447 | 0.01 | N.D. | N.D. | N.D. | N.D. | No clone |
|  | KCNA4 | Kv1.4 | ENSTGUG00000004781 | Complete | ENSGALG00000012142 | 0.04; D | ++ (↑) | + | o (↓) | + (↓) | DV952065 |
| Â | KCNA5 | Kv1.5 | ENSTGUG00000018536 | Partial | ENSGALG00000017279 | 0.10 | N.D. | N.D. | N.D. | N.D. | No clone |
# | KCNA6 | Kv1.6 | ENSTGUG00000011959 | Partial | ENSGALG00000017281 | 0.04 (1); I,D | + | + | + | + | FE733881 |
| Â | KCNA10 | Kv1.10 | ENSTGUG00000000862 | Complete | ENSGALG00000000441 | 0.03 | N.D. | N.D. | N.D. | N.D. | No clone |
KCNA Beta Subunits (voltage-gated channel beta subunits) | |||||||||||
# | KCNAB1 | HKvβ3 | ENSTGUG00000011240; ENSTGUG00000011253 | Partial | ENSGALG00000010269 | 0.02 (2) | ++ (↑) | ++ (↑) | ++ (↑) | ++ (↑) | DV947734 |
$ | KCNAB2 | HKvβ2 | ENSTGUG00000002658 | Complete | ENSGALG00000000912 | 0.07; I,D | + (↑↑) | ++ (↑↑) | ++ (↑) | + (↑) | DV957424 |
KCNB Shab-related K-Channels and Accessory Subunits | |||||||||||
KCNB Subunits - 6TM/1P (voltage-gated channel subfamily b, shab-related) | |||||||||||
| Â | KCNB1 | Kv2.1 | ENSTGUG00000008781 | Partial | ENSGALG00000004758 | < 0.01 | o | o | o | o | FE732864 |
# | KCNB2 | Kv2.2 | ENSTGUG00000011511 | Partial | ENSGALG00000022800 | 0.09 (1); D | N.D. | N.D. | N.D. | N.D. | No clone |
KCNF Modulatory Subunits - 6TM/1P (voltage-gated channel subfamily f) | |||||||||||
|  | KCNF1 | Kv5.1 | ENSTGUG00000013065 | Partial | ENSGALG00000016448 | 0.06 | + | o (↓) | o (↓) | + | DV951251 |
KCNG Modulatory Subunits - 6TM/1P (voltage-gated channel subfamily g) | |||||||||||
|  | KCNG1 | Kv6.1 | ENSTGUG00000008640 | Complete | ENSGALG00000007980 | 0.03 | + (↓) | ++ | ++ | + (↓) | CK301661 |
|  | KCNG2 | Kv6.2 | ENSTGUG00000006664 | Partial | ENSGALG00000012652 | 0.11 | N.D. | N.D. | N.D. | N.D. | No clone∑ |
| Â | KCNG3 | Kv6.3 | ENSTGUG00000003439 | Complete | ENSGALG00000009919 | 0.05; I | No signal Detected | CK313822 | |||
| Â | KCNG4 | Kv6.4 | ENSTGUG00000004343 | Partial | ENSGALG00000005502; ENSGALG00000023534* | < 0.01 (1) | N.D. | N.D. | N.D. | N.D. | No clone |
KCNS Modulatory Subunits - 6TM/1P (voltage-gated subfamily s, delayed-rectifier) | |||||||||||
|  | KCNS1 | Kv9.1 | ENSTGUG00000005049 | Partial | ENSGALG00000004074 | 0.01 | ++ (↑) | + | +++ (↑↑) | ++ (↑) | FE729668 |
# | KCNS2 | Kv9.2 | ENSTGUG00000012021 | Partial | ENSGALG00000017690 | 0.03 (1) | + (↓) | + (↓↓) | o (↓) | o | CK307490 |
| Â | KCNS3 | Kv9.3 | ENSTGUG00000013126 | Complete | ENSGALG00000016470 | 0.06 | + | + | + | + | DV958330 |
KCNV Modulatory Subunits - 6TM/1P (voltage-gated subfamily v) | |||||||||||
| Â | KCNV1 | Kv8.1 | ENSTGUG00000012266 | Complete | ENSGALG00000022481 | 0.07 | No signal Detected | CK316773 | |||
| Â | KCNV2 | Kv8.2 | ENSTGUG00000005377 | Partial | ENSGALG00000010173 | 0.02 | N.D. | N.D. | N.D. | N.D. | No clone |
#, ∆ | KCNV2L |  | ENSTGUG00000000100 | N/A | LOC100859639 | 0.04 (1, 2) | N.D. | N.D. | N.D. | N.D. | No clone |
KCNC Shaw-related K-Channels and Accessory Subunits | |||||||||||
KCNC Functional Subunits - 6TM/1P (voltage-gated subfamily c, shaw-related) | |||||||||||
|  | KCNC1 | Kv3.1 | ENSTGUG00000008821 | Partial | ENSGALG00000006220 | 0.01 | ++ (↑) | + (↑) | + (↑↑) | ++ | CK302978 |
|  | KCNC2 | Kv3.2 | ENSTGUG00000007354 | Partial | ENSGALG00000010204* | 0.01 (2) | + (↓) | ++ | + | + | DV951094 |
|  | KCNC4 | Kv3.4 | ENSTGUG00000000883 | Partial | ENSGALG00000000400* | 0.03 (2); D | N.D. | N.D. | N.D. | N.D. | CK308792†|
KCND Shab-related K-Channels and Accessory Subunits | |||||||||||
KCND Functional Subunits - 6TM/1P (voltage-gated subfamily d) | |||||||||||
# | KCND2 | Kv4.2 | ENSTGUG00000004691;ENSTGUG00000004681 | Partial | ENSGALG00000009066; ENSGALG00000021899 | 0.03 (2) | o (↓) | ++ | o (↓) | ++ | DV956417 |
|  | KCND3 | Kv4.3 | ENSTGUG00000013643 | Partial | ENSGALG00000001512 | 0.04; I,D | ++ | + (↑) | + (↓) | ++ | CK316852 |
KCND Modulatory Subunits (kv interacting protein, a-type channel modulatory protein) | |||||||||||
| Â | KCNIP1 | KChIP1 | ENSTGUG00000014900 | Partial | ENSGALG00000002132 | 0.02 | ++ | + | + | + | CK305253 |
|  | KCNIP2 | KChIP2 | ENSTGUG00000009911 | Partial | ENSGALG00000007666 | 0.03 (2); I | + | o (↓) | o (↓) | ++ (↑) | FE723960 |
| Â | KCNIP4 | KChIP4 | ENSTGUG00000009548 | Partial | ENSGALG00000014405 | 0.02 | ++ | ++ | + | + | DV959885 |
EAG, ERG, ELK K-Channels and Accessory Subunits | |||||||||||
KCNH Subunits - 6TM/1P (voltage-gated subfamily h; ether-a-gogo, ether-a-gogo-like or ether-a-gogo-related) | |||||||||||
| Â | KCNH1 | Kv10.1 | ENSTGUG00000003202 | Partial | ENSGALG00000009877 | 0.02; I | N.D. | N.D. | N.D. | N.D. | No clone |
| Â | KCNH4 | Kv10.2 | ENSTGUG00000002564 | Partial | ENSGALG00000003354 | 0.06 | N.D. | N.D. | N.D. | N.D. | No clone |
|  | KCNH5 | Kv11.2 | ENSTGUG00000012967 | Partial | ENSGALG00000011858 | 0.02 | N.D. | N.D. | N.D. | N.D. | No clone∑ |
| Â | KCNH6 | Kv11.3 | ENSTGUG00000001965 | Partial | ENSGALG00000000505 | 0.03 | N.D. | N.D. | N.D. | N.D. | No clone |
| Â | KCNH7 | Kv12.1 | ENSTGUG00000006950 | Partial | ENSGALG00000011082 | 0.04; NC | No signal Detected | DV948210 | |||
| Â | KCNH8 | Kv12.2 | ENSTGUG00000003211 | Partial | ENSGALG00000011262 | 0.01; S;C | + | + | + | + | DV957478 |
KCNE (ISK) Accessory Subunits (MinK, MiRP) - 1TM (voltage-gated subfamily e) | |||||||||||
| Â | KCNE1 | MinK | ENSTGUG00000016311 | Complete | ENSGALG00000016012 | 0.01 (1) | N.D. | N.D. | N.D. | N.D. | No clone |
#, ∆ | KCNE1P | NA | No model | N/A | No Ortholog Found | N/A (3) | N.D. | N.D. | N.D. | N.D. | No clone |
| Â | KCNE3 | MiRP2 | ENSTGUG00000013455 | Complete | ENSGALG00000022696 | < 0.01 (1,2) | No signal Detected | FE736597 | |||
| Â | KCNE4 | MiRP3 | ENSTGUG00000007898 | Complete | ENSGALG00000021057 | 0.09 | N.D. | N.D. | N.D. | N.D. | No clone |
KQT-Like K-Channels and Accessory Subunits | |||||||||||
KCNQ Subunits - 6TM/1P (voltage-gated subfamily kqt) | |||||||||||
| Â | KCNQ1 | Kv7.1 | ENSTGUG00000009167 | Partial | ENSGALG00000006472 | 0.09; S | N.D. | N.D. | N.D. | N.D. | No clone |
#, ∆ | KCNQ1L | Kv7.1 | ENSTGUG00000012696 | Partial | chr1:72414886–72434322 | N/A (3) | No signal Detected | FE721111 | |||
|  | KCNQ2 | Kv7.2 | ENSTGUG00000007434 | Partial | ENSGALG00000005822 | 0.02; S | ++ | + | + | ++ (↑) | DV954380 |
|  | KCNQ3 | Kv7.3 | ENSTGUG00000012545 | Partial | ENSGALG00000016246 | 0.09 | ++ | + (↓) | ++ | ++ (↑) | CK316820 |
# | KCNQ4 | K v 7.4 | ENSTGUG00000017337 | Partial | ENSGALG00000003200 | 0.07 (1) | N.D. | N.D. | N.D. | N.D. | No clone |
|  | KCNQ5 | Kv7.5 | ENSTGUG00000012688 | Partial | ENSGALG00000015932 | 0.09 | ++ (↑) | + | o (↓) | ++ | CK310570 |
BK, SK, IK, and Slack/Slick K-Channels and Accessory Subunits | |||||||||||
KCNMA Alpha Subunits (a.k.a. Maxi-K, Slo, BK) (calcium-activated potassium subfamily m, alpha subunits) | |||||||||||
| Â | KCNMA1 | KCa1.1/ Slo1 | ENSTGUG00000006514 | Partial | ENSGALG00000004980 | 0.02 | + | + | + | + | DV954467 |
KCNMB Beta subunit (a.k.a. Maxi-K, Slo, BK) (calcium-activated potassium subfamily m, beta subunits) | |||||||||||
|  | KCNMB1 | KCa1β1 | ENSTGUG00000014898 | Complete | ENSGALG00000002118 | 0.14 | No signal Detected | FE729268 | |||
|  | KCNMB2 | KCa1β2 | ENSTGUG00000010767 | Complete | ENSGALG00000017469 | 0.03 | N.D. | N.D. | N.D. | N.D. | DV957683†|
|  | KCNMB4 | KCa1β4 | ENSTGUG00000007043 | Complete | ENSGALG00000010044 | 0.05 | o | o | o | o | FE738514 |
KCNN Subunits (a.k.a. SK) (small conductance calcium-activated channel) | |||||||||||
| Â | KCNN1 | KCa2.1/ sk1 | ENSTGUG00000014658 | Partial | JH375632:3,234-4,841 | 0.01 (1,2) | N.D. | N.D. | N.D. | N.D. | No clone |
| Â | KCNN2 | KCa2.2/ sk2 | ENSTGUG00000001344 | Partial | ENSGALG00000002539 | 0.04 (2) | N.D. | N.D. | N.D. | N.D. | No clone |
| Â | KCNN3 | KCa2.3/ sk3 | ENSTGUG00000004125 | Partial | LOC777372 | < 0.01 (1,2) | No signal Detected | CK310929 | |||
KCNT Subunits (a.k.a. SLACK and SLICK) (subfamily t) | |||||||||||
|  | KCNT1 | KCa4.1/ slack | ENSTGUG00000006452 | Complete | ENSGALG00000001645 | 0.02 | ++ | ++ | ++ (↓) | + | FE727550 |
|  | KCNT2 | KCa4.2/ slick | ENSTGUG00000004186 | Partial | ENSGALG00000002451 | 0.04; I,D | + | + | o (↓) | +++ (↑↑) | CK310556 |
IRK, GIRK, and Related K-Channels and Accessory Subunits | |||||||||||
KCNJ Subunits (inward rectifying IRKs, GIRKs, and related) | |||||||||||
| Â | KCNJ1 | Kir1.1 | ENSTGUG00000000587 | Partial | ENSGALG00000001167 | 0.01 | N.D. | N.D. | N.D. | N.D. | No clone |
|  | KCNJ2 | Kir2.1/ irk1 | ENSTGUG00000002878 | Complete | ENSGALG00000004376 | 0.01 | N.D. | N.D. | N.D. | N.D. | FE729566†|
# | KCNJ3 | Kir3.1/ girk1 | ENSTGUG00000012153 | Partial | ENSGALG00000012537* | 0.01 | ++ | ++ (↑↑) | ++ | ++ (↑) | DV950153 |
#, ∆ | KCNJ3L |  | ENSTGUG00000002970 | N/A | ENSGALG00000009935* | 0.03 | +++ | +++ | +++ | +++ | FE722554 |
|  | KCNJ4 | Kir2.3/ irk3 | ENSTGUG00000010412 | Complete | ENSGALG00000012254 | 0.01 | N.D. | N.D. | N.D. | N.D. | CK302188†|
|  | KCNJ5 | Kir3.4/ girk4 | ENSTGUG00000000586 | Partial | ENSGALG00000001181 | 0.01 | + | + | + | + (↑) | CK315227 |
#, ∆ | KCNJ5/9 L | Chr24:252787-253805 | N/A | ENSGALG00000006922* | 0.02 (1,2) | N.D. | N.D. | N.D. | N.D. | No clone | |
|  | KCNJ6 | Kir3.2/ girk2 | ENSTGUG00000004993 | Complete | ENSGALG00000016054 | 0.01; S | ++ | ++ | + (↓) | + (↑) | FE720478 |
| Â | KCNJ8 | Kir6.1 | ENSTGUG00000012087 | Complete | ENSGALG00000013251 | 0.01; S | No signal Detected | CK312943 | |||
|  | KCNJ9 | Kir3.3/ girk3 | ENSTGUG00000015501 | Partial | No ortholog found | N/A (3) | N.D. | N.D. | N.D. | N.D. | No clone∑ |
| Â | KCNJ10 | Kir4.1 | ENSTGUG00000014138 | Complete | LOC100857799 | 0.02 (1,2) | N.D. | N.D. | N.D. | N.D. | No clone |
| Â | KCNJ11 | Kir6.2 | ENSTGUG00000008677 | Complete | ENSGALG00000020505 | N/A (3) | + | + | + | + | FE729127 |
# | KCNJ12 | Kir2.2/ irk2 | ENSTGUG00000007541 | Partial | ENSGALG00000004721* | 0.01 (1) | N.D. | N.D. | N.D. | N.D. | No clone |
| Â | KCNJ13 | Kir7.1 | ENSTGUG00000007303 | Complete | ENSGALG00000001490 | 0.09 | N.D. | N.D. | N.D. | N.D. | No clone |
| Â | KCNJ15 | Kir4.2 | ENSTGUG00000004997 | Complete | ENSGALG00000016055 | 0.03 | N.D. | N.D. | N.D. | N.D. | No clone |
| Â | KCNJ16 | Kir5.1 | ENSTGUG00000015743 | Partial | ENSGALG00000004373 | 0.02; I | N.D. | N.D. | N.D. | N.D. | No clone |
4 TRANSMEMBRANE / 2 PORE K-CHANNELS | |||||||||||
TWIK (inward rectifying), TASK (acid-sensitive), TREK (outward rectifying), THIK (halothane-inhibited), TALK (alkaline ph-activated) K-Channels - 4TM/2P (subfamily k) | |||||||||||
| Â | KCNK1 | K2P1.1/ twik1 | ENSTGUG00000010202 | Complete | ENSGALG00000011005 | 0.04 | + | + | + | + | FE734366 |
|  | KCNK2 | K2P2.1/ trek1 | ENSTGUG00000002899 | Partial | ENSGALG00000009687 | 0.03 | + | + | + | +++ (↑) | DV947959 |
| Â | KCNK5 | K2P5.1/ task2 | ENSTGUG00000007722 | Complete | ENSGALG00000010065 | 0.14; D | + | + | + | + | DV953320 |
|  | KCNK9 | K2P9.1/ task3 | ENSTGUG00000012636 | Complete | ENSGALG00000016193 | 0.01 | ++ (↑) | + | + | + | FE721255 |
| Â | KCNK10 | K2P10.1/ trek2 | ENSTGUG00000012403 | Complete | ENSGALG00000010598 | 0.23 ; NC | o | o | + | o | FE734560 |
|  | KCNK12 | K2P12.1/ thik2 | ENSTGUG00000005557 | Partial | ENSGALG00000008960* | 0.06 | + | + | o (↓) | o | FE724926 |
| Â | KCNK13 | K2P13.1/ thik1 | ENSTGUG00000012450 | Partial | ENSGALG00000010672 | 0.06; I | + | + | + | + | FE731455 |
|  | KCNK15 | K2P15.1/ task5 | ENSTGUG00000005191 | Partial | ENSGALG00000004149 | < 0.01 | N.D. | N.D. | N.D. | N.D. | DV948159†|
# | KCNK16 | K2P16.1/ talk1 | Chr3:29820700-29833238 | Partial | ENSGALG00000020049 | 0.18 (1,2) | ++ | ++ | ++ | ++ | FE723105 |
#, ∆ | KCNK16L | ENSTGUG00000013021 | N/A | ENSGALG00000012021* | 0.12; S; NC | N.D. | N.D. | N.D. | N.D. | No clone | |
|  | KCNK17 | K2P17.1/ task4 | ENSTGUG00000007716 | Partial | ENSGALG00000010068 | 0.24 | N.D. | N.D. | N.D. | N.D. | No clone∑ |
| Â | KCNK18 | K2P18.1/ tresk1 | ENSTGUG00000011054 | Complete | ENSGALG00000009265 | 0.22 (1,2); S | N.D. | N.D. | N.D. | N.D. | No clone |
BCNG (brain cyclic nucleotide gated) | |||||||||||
HCN (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel) | |||||||||||
| Â | HCN1 | HAC2 | ENSTGUG00000002345 | Partial | ENSGALG00000014875 | 0.05; D | + | + | + | + | DV957366 |
|  | HCN2 | HAC1 | ENSTGUG00000000617 | Partial | ENSGALG00000001342* | < 0.01 (2) | N.D. | N.D. | N.D. | N.D. | No clone∑ |
|  | HCN3 |  | ENSTGUG00000016537 | Partial | AADN03012245:69–809; AADN03018895:429–1605. | < 0.01 (1, 2) | N.D. | N.D. | N.D. | N.D. | No clone |
| Â | HCN4 | Â | ENSTGUG00000004104 | Complete | ENSGALG00000001764 | N/A (3) | N.D. | N.D. | N.D. | N.D. | No clone |
Note: HCN1 and HCN4 are also known to interact with KCNE2 | |||||||||||
K-CHANNEL TETRAMERIZATION (btb/poz domain proteins) | |||||||||||
|  | KCTD1 |  | ENSTGUG00000010606 | Partial | ENSGALG00000015124 | < 0.01 | N.D. | N.D. | N.D. | N.D. | FE722502†|
| Â | KCTD2 | Â | ENSTGUG00000008750 | Partial | ENSGALG00000007934 | < 0.01 | ++ | ++ | + | ++ | FE723833 |
|  | KCTD3 |  | ENSTGUG00000002895 | Partial | ENSGALG00000009678 | 0.01 (2) | ++ | + | + (↓) | ++ | CK301828 |
#, $ | KCTD4 | Â | ENSTGUG00000018368 | Complete | ENSGALG00000016975 | 0.05; S | ++ | + | ++ | + | FE727651 |
| Â | KCTD5 | Â | ENSTGUG00000009562 | Partial | ENSGALG00000006423 | 0.04 | ++ | +++ | ++ | + | CK301677 |
|  | KCTD6 |  | ENSTGUG00000009191 | Complete | ENSGALG00000007111 | < 0.01 | ++ (↑) | + | + | ++ (↑) | DV956204 |
|  | KCTD7 |  | ENSTGUG00000005372 | Partial | ENSGALG00000002618 | 0.03 (1); S | N.D. | N.D. | N.D. | N.D. | No clone∑ |
|  | KCTD8 |  | ENSTGUG00000008473 | Partial | ENSGALG00000014225 | 0.03 | N.D. | N.D. | N.D. | N.D. | FE738572†|
| Â | KCTD9 | Â | ENSTGUG00000004348 | Complete | ENSGALG00000000275 | 0.03; S | No signal Detected | FE726911 | |||
| Â | KCTD10 | Â | ENSTGUG00000007316 | Complete | ENSGALG00000005138 | < 0.01 (1) | No signal Detected | FE738173 | |||
|  | KCTD12 |  | ENSTGUG00000012550 | Partial | Chr1:1638205-1638379 | < 0.01 (1) | ++ (↓) | + (↓↓) | + (↓↓) | +++ (↑) | CK306254 |
#, ∆ | KCTD12L | ENSTGUG00000005525 | Complete | ENSGALG00000009628* | 0.06; D | o | o | o | o | FE734190 | |
| Â | KCTD14 | Â | ENSTGUG00000013019 | Partial | ENSGALG00000017266 | 0.09 | N.D. | N.D. | N.D. | N.D. | No clone |
| Â | KCTD15 | Â | ENSTGUG00000009508 | Partial | ENSGALG00000004907 | 0.03 | + | + | + | + | CK309195 |
|  | KCTD16 |  | ENSTGUG00000000129 | Partial | ENSGALG00000012322 | 0.03 | + | + | + (↓) | + | FE739532 |
| Â | KCTD17 | Â | ENSTGUG00000010672 | Partial | ENSGALG00000012486 | 0.06 | ++ | ++ | +++ | + | CK313062 |
# | KCTD18 | Â | Chr7:22311560-22315242 | Partial | ENSGALG00000008155 | 0.41 (1,2) | N.D. | N.D. | N.D. | N.D. | No clone |
|  | KCTD20 |  | ENSTGUG00000000921 | Complete | ENSGALG00000000511 | 0.07; I,D | ++ | ++ | + (↑) | + | DV959510 |
| Â | KCTD21 | Â | ENSTGUG00000013013 | Complete | ENSGALG00000017268 | 0.06 | ++ | ++ | ++ | ++ | FE733511 |
| Â | KCNRG | Â | ENSTGUG00000012112 | Partial | ENSGALG00000017012 | 0.18 | N.D. | N.D. | N.D. | N.D. | No clone |