Table 6 Gene ontology analysis of significantly over- and underrepresented genes

Biological process-overrepresented genes

Response to stress

586

17

3.60

1.34E-07

2.28E-05

G-protein coupled receptor protein signaling pathway

1042

22

6.41

3.99E-07

6.82E-05

Muscle contraction

613

17

3.77

2.50E-07

4.28E-05

Sensory perception

864

13

5.31

2.65E-03

4.53E-01

Phagocytosis

101

6

0.62

4.25E-05

7.28E-03

Macrophage activation

352

8

2.16

1.58E-03

2.71E-01

Response to stimulus

1921

22

11.81

3.19E-03

5.46E-01

Cyclic nucleotide metabolic process

109

6

0.67

6.46E-05

1.10E-02

Nerve-nerve synaptic transmission

122

7

0.75

1.20E-05

2.06E-03

Synaptic transmission

756

12

4.65

2.51E-03

4.30E-01

Biological process-underrepresented genes

Cell cycle

1867

3

11.48

2.47E-03

4.22E-01

Transcription from RNA polymerase II promoter

2343

2

14.41

3.30E-05

5.64E-03

Regulation of transcription from RNA polymerase II promoter

1780

1

10.95

1.37E-04

2.33E-02

Transcription

2353

2

14.47

3.11E-05

5.31E-03

Primary metabolic process

8037

16

49.43

3.67E-11

6.28E-09

Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

3987

8

24.52

2.75E-05

4.70E-03

Cellular component organization

1496

2

9.20

4.22E-03

7.21E-01

Mesoderm development

1621

2

9.97

2.14E-03

3.67E-01

Proteolysis

1230

1

7.56

3.69E-03

6.30E-01

Metabolic process

8351

17

51.36

1.78E-11

3.04E-09

Protein metabolic process

3295

3

20.26

6.38E-07

1.09E-04