Figure 4

Schematic representation of the main changes in gene expression and cell processes under iron-limiting conditions. Upregulated genes and pathways are shown in red, downregulated are shown in green. Large arrows indicate activation and blunt-head lines indicate repression by the respective transcription regulator (Fur is represented as iron-bound). Thin arrows indicate enzyme reactions. Traced arrow indicates activation of the enzyme GlnB by GlnD via uridylylation. L-hCys: L-homocysteine, SAM: S-adenosylmethionine, SAhC: S-adenosylhomocysteine.