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Table 4 Genes downregulated exclusively in response to iron limitation

From: Global transcriptional response of Caulobacter crescentus to iron availability

Gene CB15

Gene NA1000

Predicted function

Fold changea

Amino acid metabolism

CC_0049

CCNA_00047

tRNA m7-G46 methyltransferase

−3.12

CC_0050

CCNA_00048

S-adenosylmethionine synthetase

−3.05

CC_0167

CCNA_00166

Hypothetical protein (transglutaminase-like cysteine proteinase)

−2.22

CC_0257

CCNA_00257

Adenosylhomocysteinase

−3.12

CC_0482

CCNA_00515

Cobalamin-independent methionine synthase (Zinc)

−2.49

CC_0984

CCNA_01035

Gamma-glutamyltranspeptidase

−2.68

CC_1048

CCNA_01100

Acylamino-acid-releasing enzyme

−2.73

CC_2137

CCNA_02221

Methionine synthase I metH (Zinc)

−2.52

CC_2138

CCNA_02222

5-methyltetrahydrofolate

−2.72

CC_2139

CCNA_02223

Beta-lactamase, type II (Zinc)

−2.83

CC_2140

CCNA_02224

Methylenetetrahydrofolate reductase

−2.39

CC_2840

CCNA_02933

Aminopeptidase

−2.14

CC_3044

CCNA_03139

Dihydroxy-acid dehydratase (Fe-S cluster)

−3.35

CC_3246

CCNA_03355

Acylamino-acid-releasing enzyme

−2.20

CC_3606

CCNA_03721

Glutamate synthase (NADPH) small chain

−2.30

CC_3607b

CCNA_03722

Glutamate synthase (NADPH) large chain (Fe-S cluster)

−2.51

Chemotaxis and motility

CC_0430

CCNA_00439

Methyl-accepting chemotaxis protein

−2.97

CC_0431

CCNA_00440

CheX protein

−2.50

CC_0432

CCNA_00441

Chemotaxis receiver domain protein cheYI

−2.31

CC_0433

CCNA_00442

Chemotaxis histidine kinase protein cheAI

−2.11

CC_0901

CCNA_00946

Basal-body rod modification protein FlgD

−2.38

CC_0902

CCNA_00947

Flagellar hook protein FlgE

−2.23

CC_1399

CCNA_01465

Methyl-accepting chemotaxis protein

−2.22

CC_1456

CCNA_01523

Acetyltransferase flmH

−2.63

CC_2846

CCNA_02939

Conserved hypothetical protein

−5.24

CC_2847

CCNA_02940

Methyl-accepting chemotaxis protein

−3.44

Energy Metabolism

CC_1942

CCNA_02020

NADH-quinone oxidoreductase chain I (Fe-S cluster)

−2.12

CC_1943

Unannotated

Hypothetical protein

−2.20

CC_1944

CCNA_02021

Hypothetical protein

−2.26

CC_1946

CCNA_02023

NADH-quinone oxidoreductase chain G (Fe-S cluster)

−2.05

CC_1953b

CCNA_02030

Hypothetical protein

−2.19

CC_3525b

CCNA_03640

Ferredoxin reductase subunit (Fe-S cluster)

−2.30

CC_3659

CCNA_03774

Citrate lyase beta chain/citryl-CoA lyase subunit

−2.00

CC_3667

CCNA_03781

Aconitate hydratase (Fe-S cluster)

−2.30

Miscellaneous

CC_0566

CCNA_00601

MoxR-like ATPase

−2.04

CC_1409b

CCNA_01475

OmpW family outer membrane protein

−3.21

CC_1754b

CCNA_01830

TonB-dependent receptor

−2.07

CC_2389

CCNA_02472

Cobalt-zinc-cadmium resistance protein czcB

−2.42

CC_3081

CCNA_03177

Methylmalonyl-CoA mutase MeaA-like protein

−2.55

CC_3127b

CCNA_03227

TonB-dependent receptor

−2.41

CC_3413

CCNA_03524

Di-/tripeptide transporter (Major Facilitator Superfamily)

−2.48

CC_3461b

CCNA_03574

TonB-dependent receptor

−2.70

Hypothetical

CC_0600

CCNA_00636

Hypothetical protein

−2.16

CC_1068

CCNA_01121

Conserved hypothetical protein

−2.40

CC_1102

CCNA_01158

Hypothetical protein

−2.47

CC_2745b

CCNA_02831

Conserved hypothetical protein (DUF2272)

−3.14

CC_3412

CCNA_03523

Hypothetical protein (Acetyltransferase (GNAT) family)

−2.18

  1. a Values are fold changes in the expression levels as described in Table 3. Negative values denote downregulation.
  2. bThese genes are probably also downregulated in the fur mutant since their expression changes were very close to our cutoff criterion.