Skip to main content

Table 10 Mutations induced in the PRE

From: PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer’s amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE)

Variant

Sites deleted

Sites created

Wildtype PRE

  

M1

AP2, GATA1, GC Box (II)a, PuF, R, SP1 (I)b

AML1a

M2

AP2, GC Box (I), GATA1, Pax4α, PuF, SP1 (I)

AML1a/AML1c, AP4, GT-IIBα

M3

R, TCERG (I)c

 

M4

GATA1/GATA2, SP1 (II)

GR, PR

M5

R, TCERG (I)

YY1

M6

TCERG1 (II)

GATA1/GATA2

M7

TCERG1 (I, II), R

 
  1. aTwo distinct GC boxes were identified in the wildtype PRE sequence and are designated as “I” and “II”.
  2. bTwo distinct SP1 sites in addition to the GC boxes were identified in the wildtype PRE sequence and are designated as “I” and “II”.
  3. cTwo distinct TCERG1 sites were identified in the wildtype PRE sequence and are designated as “I” and “II”.
Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us