Table 4 Gene expression modified by PDR8 allelic switch
ORF | Name | eQTL | LogFC | AdjPv | SGD function |
|---|---|---|---|---|---|
YIL121W | QDR2 | hotspot8 | 2,234 | <10e-05 | Multidrug transporter of the major facilitator superfamily required for resistance to quinidine barban cisplatin and bleomycin |
YLR179C | YLR179C | hotspot8 | 0,897 | 0,0026 | Protein of unknown function transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance |
YLR149C | YLR149C | - | 1,349 | <10e-05 | Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport |
YCR098C | GIT1 | - | 0,548 | 0,005 | Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate |
YIL120W | QDR1 | - | 0,472 | 0,0046 | Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban |
YLR266C | PDR8 | chr16:138 | −0,493 | 0,0032 | Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon |