The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice

Table 3 C. pneumoniae infection-enriched GO terms in the inguinal AT transcriptome

GO category	Enriched GO term	GO term p-value^a	GO term-associated gene products
GO category	Enriched GO term	GO term p-value^a	Up-regulated^b	Down-regulated^b
GO:0035634	Response to stilbenoid	<0.001	Ifit3, Usp18	-
GO:0019785	ISG15-specific protease activity	<0.001	Usp18	-
GO:0032020	ISG15-protein conjugation	<0.001	Usp18	-
GO:0001823	Mesonephros development	0.001	Osr2, Gpc3	-
GO:0033687	Osteoblast proliferation	0.002	Osr2, Eif2ak2	-
GO:0035116	Embryonic hindlimb morphogenesis	0.003	Osr2, Gpc3	-
GO:2000543	Positive regulation of gastrulation	0.008	Osr2	-
GO:0061029	Eyelid development in camera-type eye	0.008	Osr2	-
GO:0060272	Embryonic skeletal joint morphogenesis	0.008	Osr2	-
GO:0048793	Pronephros development	0.008	Osr2	-
GO:0030282	Bone mineralization	0.013	Osr2, Gpc3	-
GO:0001656	Metanephros development	0.013	Osr2, Gpc3	-
GO:0042474	Middle ear morphogenesis	0.020	Osr2	-
GO:0004221	Ubiquitin thiolesterase activity	0.020	Usp18	-
GO:0035115	Embryonic forelimb morphogenesis	0.030	Osr2	-
GO:0030501	Positive regulation of bone mineralization	0.030	Osr2	-
GO:0048523	Negative regulation of cellular process	0.036	Slfn1, Gpc3, Ppap2b, Eif2ak2, Osr2	Acaa2, Ddit4
GO:0030163	Protein catabolic process	0.042	Usp18, Gpc3	-
GO:0050678	Regulation of epithelial cell proliferation	0.042	Osr2, Gpc3	-
GO:0043401	Steroid hormone mediated signaling pathway	0.042	-	Nr1d2

^aP-values are corrected for multiple hypotheses using Benjamini-Hochberg false discovery rate.
^bFold change limit 2.0.
Number of biological replicates is 3.
GO, gene ontology. The maximum of 20 GO categories is shown.

ISSN: 1471-2164