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Table 6 C. pneumoniae infection-enriched GO terms in the epididymal AT transcriptome

From: The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice

GO category

Enriched GO term

Go term p-valuea

GO term-associated gene products

Up-regulatedb

Down-regulatedb

GO:0009206

Purine ribonucleoside triphosphate biosynthetic process

<0.001

Nme7, Atp1b1, Ldhc,1600029I14Rik

-

GO:0006754

ATP biosynthetic process

<0.001

Nme7, Atp1b1, Ldhc

-

GO:0005391

Sodium:potassium-exchanging ATPase activity

<0.001

Nme7, Atp1b1

-

GO:0031957

Very long-chain fatty acid-CoA ligase activity

<0.001

Acsbg1, Slc27a2

-

GO:0030317

Sperm motility

<0.001

Spag6, Tnp1, Ldhc, Smcp

-

GO:0004467

Long-chain fatty acid-CoA ligase activity

<0.001

Acsbg1, Slc27a2

-

GO:0006952

Defense response

0.003

Ccl8, Arg2, Defb22, Cx3cl1, Nt5e, Defb29, Defb36, Defb38, Cfi, Elf3

Ccl5, Orm1, Orm2, S100a8, Ccl11

GO:0001676

Long-chain fatty acid metabolic process

0.003

Acsbg1, Slc27a2

-

GO:0000038

Very long-chain fatty acid metabolic process

0.003

Acsbg1, Slc27a2

-

GO:0006323

DNA packaging

0.004

Sox9, Prm1

Hist1h4i, Hist2h2ac, Hist1h4k, Hist1h4j, Hist1h3d

GO:0016338

Calcium-independent cell-cell adhesion

0.005

Cldn2, Cldn11, Cx3cl1

 

GO:0009991

Response to extracellular stimulus

0.007

Slc39a4, Mt3, Srd5a2, Sox9, Lrp2, Sfrp1, Arg2, Avpr1a

Tnfrsf11b, Ccl5, Acta1

GO:0034728

Nucleosome organization

0.008

Sox9, Tnp1

Hist1h3d, Hist2h2ac, Hist1h4i, Hist1h4k, Hist1h4j

GO:0071345

Cellular response to cytokine stimulus

0.008

Mt3, Cx3cl1, Krt18, Sox9, Krt8, Sfrp1, Arg2

Ccl5

GO:0042493

Response to drug

0.008

Slc15a2, Mt3, Srd5a2, Lrp2, Sfrp1, Arg2, Slc22a1

Tnfrsf11b, Ccl5, Cox8b

GO:0048245

Eosinophil chemotaxis

0.009

LOC100048554

Ccl5, Ccl11

GO:0022414

Reproductive process

0.009

Spag6, Sox9, 4931407G18Rik, Avpr1a, Arg2, Prm1, Tnp1, Odf2, Smcp, Acsbg1, Cldn11, Srd5a2, Mycbpap, Sfrp1

Ccl5

GO:0006333

Chromatin assembly or disassembly

0.009

Sox9, Tnp1

Hist1h3d, Hist2h2ac, Hist1h4i, Hist1h4k, Hist1h4j,

GO:0048609

Multicellular organismal reproductive process

0.010

4931407G18Rik, Avpr1a, Arg2, Prm1, Spag6, Smcp, Odf2, Sfrp1, Cldn11, Mycbpap, Sox9, Tnp1

-

GO:0032504

Multicellular organism reproduction

0.010

Sox9, 4931407G18Rik, Arg2, Prm1, Spag6, Avpr1a, Odf2, Sfrp1, Cldn11, Tnp1, Mycbpap, Smcp

-

  1. aP-values are corrected for multiple hypotheses using Benjamini-Hochberg false discovery rate.
  2. bFold change limit 2.0.
  3. Number of biological replicates is 3.
  4. GO, gene ontology. The maximum of 20 GO categories is shown.
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BMC Genomics

ISSN: 1471-2164

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