The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice

Table 7 Combined chronic C. pneumoniae and recurrent A. actinomycetemcomitans infections-enriched GO terms in the epididymal AT transcriptome

GO category	Enriched GO term	Go term p-value^a	GO term-associated gene products
GO category	Enriched GO term	Go term p-value^a	Up-regulated^b	Down-regulated^b
GO:0045653	Negative regulation of megakaryocyte differentiation	<0.001	-	Hist1h4h, Hist1h4i, Hist1h4k, Hist1h4j
GO:0006334	Nucleosome assembly	<0.001	Sox9	Hist1h4j, Hist1h4i, Hist1h4k, Hist1h4h, Hist1h3d, Hist2h2ac
GO:0005515	Protein binding	<0.001	BC021891, Lrrc48, Gja1, Cldn2, Lrtm1, Pcp4l1, Cldn11, Ubd, Dynlrb2, Mt3, Clic6, Sh3gl2, Lrp2, Nme7, Slc40a1, Cxcl13, Fcgr4, Spag6, Ccl8, Sox9, Alox12, Sfrp1, Ighv1-62, Col6a5, C7, Ighg3, Ighg, LOC100047788, Igk-C, D6Mit97, Igk-V5, Igkv12-46, LOC384419, LOC637227, Igkv4-68	Itga11, Acta1, Bmp3, Sfrp5, Hist1h4i, Hist1h4h, Hist1h4k, Wdr92, Hist1h3d, Hist1h4j
GO:0003823	Antigen binding	<0.001	LOC100047788, Igk-C	-
GO:0016337	Cell-cell adhesion	0.004	Sox9, Cxcl13, Cldn11, 1110049B09Rik, Cldn2, Dsg2	Chst4
GO:0016338	Calcium-independent cell-cell adhesion	0.011	Cldn2, Cldn11	-
GO:2000117	Negative regulation of cysteine-type endopeptidase activity	0.016	Sfrp1, Mt3	-
GO:0019731	Antibacterial humoral response	0.016	LOC100047788	-
GO:0019730	Antimicrobial humoral response	0.016	LOC100047788	-
GO:0008219	Cell death	0.016	Mt3, Alox12, Sox9, Slc40a1, Sfrp1, Acsbg1, Mmd2, Ubd, Bex2, Dsg2, Gja1	Lyz1, Wdr92
GO:0071504	Cellular response to heparin	0.021	Sfrp1, Sox9	-
GO:0006352	Transcription initiation, DNA-dependent	0.021	-	Hist1h4h, Hist1h4i, Hist1h4k, Hist1h4j
GO:0019835	Cytolysis	0.024	Mmd2	Lyz1
GO:0008253	5′-nucleotidase activity	0.041	Nt5e, Acpp	-

^aP-values are corrected for multiple hypotheses using Benjamini-Hochberg false discovery rate.
^bFold change limit 2.0.
Number of biological replicates is 3.
GO, gene ontology. The maximum of 20 GO categories is shown.

ISSN: 1471-2164