Table 2 Modular enrichment analysis
Gene module | Module correlation to EtOH consumption | P value of correlation to consumption | Differentially expressed (DE) genes in module | Module size | P value of enrichment in DE genes | Functional category enrichment | Cell type-specific enrichment |
|---|---|---|---|---|---|---|---|
Red | 0.63 | 1.08E-04 | 74 | 307 | 5.02E-16 | Vesicle-mediated transport, Endocytosis | Oligodendrocytes |
Brown | 0.55 | 1.23E-03 | 88 | 846 | 6.72E-02 | Transport, Synaptic transmission, Toll-like receptor & chemokine signaling | Neurons, Astrocytes |
Pink | 0.47 | 6.28E-03 | 30 | 150 | 1.89E-05 | Cellular component organization or biogenesis, endosomal transport | - |
Blue | 0.35 | 4.77E-02 | 104 | 936 | 9.16E-03 | Synaptic transmission, Neurotransmitter secretion | Neurons, Astrocytes, Oligodendrocytes |
Black | 0.13 | 0.47 | 1 | 306 | 1 | Regulation of developmental process, Neurogenesis | Astrocytes, Neurons, Oligodendrocytes |
Grey | 0.04 | 0.85 | 15 | 3339 | 1 | - | Neurons, Oligodendrocytes |
Magenta | -0.08 | 0.65 | 0 | 130 | 1 | Blood vessel development, Angiogenesis, BMP signaling | Astrocytes, Microglia |
Green | -0.40 | 2.44E-02 | 10 | 445 | 1 | Oxidative phosphorylation, Ribosome biogenesis | Astrocytes |
Turquoise | -0.63 | 1.08E-04 | 224 | 1125 | 9.85E-36 | Synaptic transmission, Chemokine signaling, Toll-like receptor signaling | Neurons, Astrocytes |
Yellow | -0.74 | 1.35E-06 | 196 | 719 | 1.90E-52 | Electron transport chain, Translation, Ribosome biogenesis | - |