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Table 1 Top-5 over-represented GO/Biological process terms in exonic repeat-associated genes by species

From: Repeat-encoded poly-Q tracts show statistical commonalities across species

Saccharomyces cerevisiae

GO term

E-value

Term description

GO:0050789

2.35E-06

regulation of biological process

GO:0060255

8.91E-06

regulation of macromolecule metabolic process

GO:0050794

9.14E-06

regulation of cellular process

GO:0019222

9.40E-06

regulation of metabolic process

GO:0048522

1.49E-05

positive regulation of cellular process

Arabidopsis thaliana

GO term

E-value

Term description

GO:0016070

7.32E-10

RNA metabolic process

GO:0090304

1.59E-09

nucleic acid metabolic process

GO:0044260

1.78E-09

cellular macromolecule metabolic process

GO:0009889

2.61E-09

regulation of biosynthetic process

GO:0043170

2.74E-09

macromolecule metabolic process

Caenorhabditis elegans

GO term

E-value

Term description

GO:0007265

2.22E-08

Ras protein signal transduction

GO:0046578

7.32E-08

regulation of Ras protein signal transduction

GO:0050794

1.29E-07

regulation of cellular process

GO:0009966

5.92E-07

regulation of signal transduction

GO:0051056

1.11E-06

regulation of small GTPase mediated signal transduction

Drosophila melanogaster

GO term

E-value

Term description

GO:0048856

5.57E-106

anatomical structure development

GO:0048731

3.19E-100

system development

GO:0007275

8.55E-95

multicellular organismal development

GO:0032502

9.65E-95

developmental process

GO:0048513

1.10E-90

organ development

Mus musculus

GO term

E-value

Term description

GO:0032502

3.76E-45

developmental process

GO:0007399

4.92E-42

nervous system development

GO:0007275

2.98E-41

multicellular organismal development

GO:0048856

2.61E-39

anatomical structure development

GO:0048869

3.83E-39

cellular developmental process

Homo sapiens

GO term

E-value

Term description

GO:0007399

1.15E-20

nervous system development

GO:0030030

5.48E-16

cell projection organization

GO:0032989

6.39E-16

cellular component morphogenesis

GO:0048666

2.81E-15

neuron development

GO:0000902

3.76E-15

cell morphogenesis

  1. Note that for Drosophila melanogaster, Mus musculus and Homo sapiens, the top-5 terms are development-related, yet many regulation-related terms appear at statistically significant levels (not shown).