The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi’s sarcoma associated herpesvirus reactivation

Table 3 Top 20 potential SUMO-1 targeting TFs after KSHV reactivation

Rank	Name	Transfac	TFBS # (in TSS±500 bp)	Peak # of TFBS (in TSS±500 bp)		% of TFBS Peak (in TSS±500 bp)		Gene #
Rank	Name	Transfac	TFBS # (in TSS±500 bp)	0 h	12 h	0 h	12 h	0 h	12 h
1	ETS1	V$CETS1P54_01	1587	341	262	21.5%	16.5%	294	229
2	STAT4	V$STAT4_01	106	17	17	16.0%	16.0%	4	4
3	ELK1	V$ELK1_02	1667	333	254	20.0%	15.2%	279	215
4	GABPA/NRF-2	V$NRF2_01	1577	336	237	21.3%	15.0%	286	206
5	STAT1	V$STAT1_03	282	50	41	17.7%	14.5%	48	39
6	NFATC1/2/3/4	V$NFAT_Q6	487	48	70	9.9%	14.4%	22	23
7	STAT5A	V$STAT5A_02	982	118	129	12.0%	13.1%	95	104
8	MYC/MAX	V$MYCMAX_02	580	90	76	15.5%	13.1%	68	55
9	CREB1	V$CREB_01	666	103	87	15.5%	13.1%	97	83
10	CUTL1	V$CDPCR1_01	582	59	73	10.1%	12.5%	54	49

ISSN: 1471-2164