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Table 5 Kinases with common targets encoded by the EGF-, EphrinAs- and SP600125-regulated genes

From: Profiling and metaanalysis of epidermal keratinocytes responses to epidermal growth factor

Kinase

EGF 1&4 h UP

SP 1&4 h DN

EFNAs DN

MAPK1

2.51E-07

1

1.22E-02

SRC

5.21E-06

1

1

MAPK14

1.36E-05

1

1.88E-04

EGFR

1.39E-05

1

1

INSR

1.02E-04

1

1

MAPK3

1.70E-04

1

5.05E-02

JAK2

3.57E-04

1

1

ROCK1

2.62E-03

1

1

JAK1

3.30E-03

1

1

PTK2

3.62E-03

1

1

MAPK8

2.92E-02

1

1

PRKCQ

4.00E-02

1

1

ERBB2

5.35E-02

1

1

FYN

5.36E-02

1

1

JAK3

5.45E-02

1

1

IGF1R

7.63E-02

1

1

PRKCD

9.07E-02

1

1

 

EGF 24&48 h DN

SP 24&48 h UP

EFNAs UP

CDK2

5.84E-03

1.43E-04

1

CDC2

1.21E-02

2.45E-06

1

  1. UP denotes induced, DN suppressed genes. All kinases with p-values better than 0.1 for the EGF-regulated targets are listed. No kinases common to all three agents were identified.
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BMC Genomics

ISSN: 1471-2164

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