Zebrafish gene | Fold change | Functions | Hematopoiesis-associated phenotypes | Human homolog | Reference |
---|---|---|---|---|---|
alas2 | ↓1.44 | First enzyme of heme synthesis | X-linked sideroblastic anemia | ALAS2 | [51] |
tfa | ↓1.89 | Fe(III)-carrier in plasma | Severe anemia | TF | [52] |
tfr1b | ↓2.75 | Membrane receptor for Fe(II)-TF | Embryonic lethality and hematopoietic defect | TFRC | [53] |
aco2 | ↓1.3 | Bind to IREs; Fe sensors | Microcytic anemia | IRP2 | [54] |
fth1a | ↓1.35 | Prevents Fe toxicity during erythropoiesis | Embryonic lethality | FTH1 | |
fth1b | ↓1.83 | ||||
slc25a37 | ↓1.77 | Iron transport into mitochondria | Embryonic lethal with profound anemia; hypochromic anemia | SLC25A37 | |
cp | ↓2.88 | Oxidizes exported Fe2+ | Hypochromic microcytic anemia | CP | [59] |
htt | ↓1.27 | Transferrin receptor trafficking | Hypochromic anemia | HTT | [60] |
sfxn1 | ↓2.19 | Mitochondrial transport and iron metabolism | Siderocytic anemia | SFXN1 | [61] |
zgc:194125 | ↑2.73 | Iron homeostasis and heme synthesis | Sideroblastic anemia | FTMT | |
zgc:109934 | ↑2.36 | ||||
zgc:173594 | ↑4.12 |  |  |  |  |