Table 2 IWPC African American GWAS Cohort patient data, regression coefficients, p-values
From: Pathway analysis of genome-wide data improves warfarin dose prediction
Covariate | Mean/% Patients | Standard Deviation | Coefficient | p-value |
|---|---|---|---|---|
Age | 56.81 | 14.66 | -0.350 | 1.32E-07 |
Weight (kg) | 94.55 | 28.07 | 0.136 | 1.27E-04 |
Height (cm) | 171.7 | 10.642 | 0.243 | 0.0105 |
Amiodarone | 4.68% | - | -13.155 | 2.02E-03 |
Aspirin | 27.49% | - | -7.21 | 9.58E-04 |
VKORC1 rs9923231 GG | 82.16% | - | - | - |
VKORC1 rs9923231 AG | 16.96% | - | -7.422 | 3.39E-03 |
VKORC1 rs9923231 AA | 0.88% | - | -31.481 | 1.03E-03 |
CYP2C9*2 rs1799853 AG | 4.09% | - | -2.66 | 0.593 |
CYP2C9*2 rs1799853 GG | 95.91% | - | - | - |
CYP2C9*3 rs1057910 GT | 2.34% | - | -14.91 | 0.0176 |
CYP2C9*3 rs1057910 TT | 97.66% | - | - | - |
Principal Component 1 | - | 27.44 | -0.00943 | 0.784 |
Principal Component 2 | - | 24.42 | -0.00697 | 0.864 |
A#m Metabolic Pathway | 29.71 | 7.25 | -0.331 | 0.0135 |