Figure 3

Histograms of genes affected by all missense mutations and predicted functional mutations built for six types of cancer: (A) each of the histograms represent the total number of genes (Genes tot) affected by at least one of missense or truncating mutations (MM+TM); the effective number of genes (Eq.6) affected by at least one of missense or truncating mutations ("Genes eff (MM+TM)"), the effective number of genes affected by at least one of predicted functional or truncating mutations ("Genes eff (FIS>2.5+TM)"); (B) the histograms represent the total number of cancer genes (CanGene) affected by at least one of missense or truncating mutations (MM+TM); the effective number of cancer genes affected by at least one of missense or truncating mutations, the effective number of cancer genes affected by at least one of predicted functional or truncating mutations (FIS>2.5+TM).