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Figure 2 | BMC Genomics

Figure 2

From: Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia

Figure 2

Workflow to determine core pathways and driver mutations. (A) mutated genes (blue filled circle) and differentially expressed genes (green filled circle) are mapped to a protein-protein interaction network in which the circles and lines represent proteins and interactions between them, respectively. (B) The shortest-path algorithm is applied to construct subnetworks by linking the mutated genes to up-, or down-regulated genes, respectively. (C) BiNGO is applied to identify overrepresented biological pathways. (D) The experimentally validated driver pathway is used to rank the driver mutations.

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BMC Genomics

ISSN: 1471-2164

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