Table 4 REPTree regression correlation coefficients (r) using TSM positions for both NRTIs and NNRTIs to construct structure-based mutant feature vectors
From: Sequence and structure based models of HIV-1 protease and reverse transcriptase drug resistance
| Â | NRTIs | NNRTIs | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Train/Test | 3TC | ABC | AZT | d4T | ddC | ddI | FTC | TDF | DLV | EFV | NVP |
NRTIs | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
3TC | 0.99 | 0.71 | -0.05 | 0.04 | 0.45 | 0.39 | 1.00 | -0.29 | -0.11 | -0.16 | -0.23 |
ABC | 0.83 | 0.92 | 0.28 | 0.44 | 0.64 | 0.67 | 0.91 | 0.02 | -0.13 | -0.08 | -0.17 |
AZT | 0.07 | 0.39 | 0.90 | 0.75 | 0.17 | 0.28 | 0.34 | 0.63 | -0.03 | 0.02 | -0.01 |
d4T | 0.17 | 0.55 | 0.76 | 0.93 | 0.56 | 0.64 | 0.36 | 0.56 | -0.11 | -0.04 | -0.08 |
ddC | 0.57 | 0.67 | 0.15 | 0.48 | 0.90 | 0.85 | 0.93 | -0.03 | -0.14 | -0.14 | -0.20 |
ddI | 0.41 | 0.69 | 0.28 | 0.63 | 0.85 | 0.92 | 0.70 | 0.13 | -0.12 | -0.06 | -0.12 |
FTC | 0.94 | 0.67 | -0.02 | 0.02 | 0.42 | 0.35 | 0.99 | -0.30 | -0.15 | -0.19 | -0.26 |
TDF | -0.46 | -0.03 | 0.68 | 0.57 | -0.08 | 0.04 | -0.41 | 0.86 | 0.04 | 0.09 | 0.10 |
NNRTIs | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
DLV | -0.15 | -0.12 | 0.08 | 0.01 | -0.08 | -0.09 | -0.33 | -0.01 | 0.89 | 0.60 | 0.68 |
EFV | -0.09 | -0.01 | 0.12 | 0.04 | -0.09 | -0.04 | -0.13 | 0.04 | 0.64 | 0.93 | 0.79 |
NVP | -0.13 | -0.05 | 0.16 | 0.08 | -0.13 | -0.09 | -0.21 | 0.03 | 0.63 | 0.72 | 0.93 |