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Table 4 The AUC performance comparison of MHC2SKpan with MutliRTA, TEPITOPEpan, NetMHCIIpan-1.0 and NetMHCIIpan-2.0 on EpanSet4. For each allele, we display the largest value in boldface. The last row is the average result by excluding two alleles in NielsenSet3, DRB1*03:02 and DRB1*12:01.

From: MHC2SKpan: a novel kernel based approach for pan-specific MHC class II peptide binding prediction

allele

count

MultiRTA

TEPITOPEpan

NetMHCIIpan-1.0

NetMHCIIpan-2.0

MHC2SKpan

DRB1*01:02

92

0.749

0.758

0.785

0.746

0.752

DRB1*01:03

52

0.772

0.867

0.756

0.772

0.798

DRB1*03:02

88

0.733

0.823

0.775

0.840

0.761

DRB1*04:03

63

0.611

0.762

0.659

0.678

0.714

DRB1*04:06

92

0.519

0.501

0.557

0.486

0.489

DRB1*11:02

65

0.591

0.738

0.738

0.774

0.766

DRB1*11:03

64

0.585

0.726

0.623

0.791

0.785

DRB1*11:04

73

0.618

0.654

0.639

0.737

0.740

DRB1*12:01

719

0.673

0.659

0.721

0.740

0.753

DRB1*13:01

302

0.567

0.623

0.516

0.494

0.485

DRB1*14:01

43

0.809

0.785

0.761

0.676

0.721

DRB1*15:02

47

0.777

0.742

0.762

0.888

0.899

DRB1*16:01

56

0.789

0.644

0.793

0.814

0.817

DRB3*02:02

656

0.680

0.686

0.732

0.806

0.789

Average

2412

0.677

0.712

0.701

0.732

0.734

Average*

1605

0.672

0.707

0.693

0.722

0.730