Figure 2

Pathway and process enrichment results of reported target genes of 15 dysregulated miRNAs. (A) The respective pathway enrichment results and (B) the process enrichment results of known targets for both upregulated miRNA (orange) and downregulated miRNA (blue) were generated by MetaCore. The horizontal axis is the negative log transformation of the P value, which indicates the probability that these processes (or pathways) are raised by chance. In pathway enrichment, numerous pathways related to cancer, such as cell proliferation, cell cycles, cytoskeleton remodeling, and EMT, are statistically enriched. A similar outcome is found in process enrichment, and many cancer- or metastasis-correlated processes are enriched.