Co-modulated behavior and effects of differentially expressed miRNA in colorectal cancer

BMC Genomics

Table 1 The top 20 most differential up- and downregulated miRNAs are shown from 2 miRNA profiles.

Upregulated miRNAs	T1^a	M1^b	T2^c	M2^d
miR-183	25.6	22.9	3.8	9.1
miR-31	22.5	18.6	5.7 1	3.8
miR-135b	8.6	6.6	18.2	46.5
miR-96	8.3	8.6	6.7	65.3
miR-224	7.1	4.7	13.1	43.1
miR-182	5.2	5.7	2.1	6.5
miR-193a-5p	4.7	3.7	1.4	3.5
miR-409-5p	4.7	11.8	1	8.2
miR-18b	4.3	1.5	10.9	8.7
miR431	3.8	7.4	10.1	11
miR-18a	3.7	1.3	5.1	6.8
miR-221	3.2	1.1	4.8	5.3
miR-424	2.3	2	1.6	7.2
miR-25	1.6	1.9	3.8	5.1
miR-29b	1.5	2.6	2.4	7.3
miR-455-3p	1.5	2.2	9.7	46.2
miR-93	1.4	2.2	5.3	6.9
miR-483-5p	1.1	9.7	19.5	128
miR-455-5p	1.1	2.1	2.7	5.5
miR-122	1	201441.3	1	1370
Downregulated miRNAs
miR-137	0.005	0.004	0.108	0.136
miR-133b	0.025	0.03	0.403	0.271
miR-133a	0.026	0.021	0.236	0.052
miR-138	0.038	0.061	0.566	0.255
miR-204	0.043	0.697	0.066	0.479
miR-342-3p	0.073	0.619	0.059	0.064
miR-9	0.079	0.223	0.291	0.447
miR-195	0.085	0.19	0.517	0.287
miR-143	0.097	0.118	0.435	0.366
miR-139-5p	0.112	2.1	0.167	0.87
miR-140-3p	0.113	0.269	0.343	0.554
miR-196a/b	0.125	0.001	0.031	0.015
miR-1	0.146	0.012	0.586	0.384
miR-10b	0.156	0.037	0.779	0.279
miR-218	0.166	0.297	0.213	1.2
let-7b	0.203	0.506	0.726	0.646
miR-149	0.204	0.162	0.174	0.801
miR-145	0.205	0.153	0.438	0.514
miR-147b	0.251	0.152	0.122	0.025
miR-215	0.489	0.23	0.318	0.619

The expression patterns of 15 miRNA candidates that proved consistent with the profile data after further confirmation in addition to the 6 CRC samples are shown in bold.
a. Primary colon cancer: adjacent mucosa from patient 1
b. Liver metastases: adjacent mucosa from patient 1
c. Primary colon cancer: adjacent mucosa from patient 2
d. Liver metastases: adjacent mucosa from patient 2

ISSN: 1471-2164