Figure 5

Summary of screening hits for all pathogens. (A) The heat map shows all genes which were significant (FDR < 0.4) at least for one pathogen. We ordered the genes by their averaged c-values over all pathogens. The colors correspond to the estimated c-values. The black outlines indicate significant hits (FDR < 0.4) and the green outlines high-light the strongest down and up hits for each pathogen. The rightmost column shows the sharedness scores for each gene. (B) The network shows the hit genes (FDR < 0.4 for at least one pathogen) and their direct neighbors that had connections between kinases in STRING database (version 9.0). The edges are functional interactions in the STRING database with edge threshold 850. We removed genes that were not connected to any other gene from the network. Each node consists of a colored pie chart, in which each piece corresponds to a pathogen.