Figure 3From: A hyper-dynamic nature of bivalent promoter states underlies coordinated developmental gene expression modulesGene expression level correlates with chromatin signature complexity. (A) Heat maps of chromatin state enrichment in gene regions (gene length ± 10 kb) for each expression cluster during adipogenic differentiation. Gene ratios (see text) at each differentiation time point are scaled from low-to-high and reflect chromatin state ‘loads’. Time point transitions at which a difference in gene ratios is significant are marked (dot; P < 0.05; t-test with Bonferroni correction). (B) Matrix of statistically significant differences in global state enrichment between expression clusters; P-values are shown in Additional file 2: Table S6A; Wilcoxon test with Bonferroni correction. (C) Chromatin states and RNA-seq profiles at the inactive EOMES locus and at the expressed adipogenic SREBF1 locus; FPKM ranges are shown. (D) Regression analysis of gene expression level as a function of the number of chromatin states, i.e. complexity of chromatin signatures, in gene regions.Back to article page