Figure 4From: A hyper-dynamic nature of bivalent promoter states underlies coordinated developmental gene expression modulesTemporal and dynamic changes in chromatin states. (A) Numbers of significant chromatin state changes (all clusters confounded) at the D0/D3 and D3/D9 transitions (t-test with Bonferroni correction). (B) Dynamics of chromatin states in each expression cluster. Graphs represent the sum of changes in P-values for each cluster. (C) Matrix of significant differences in chromatin state dynamics between clusters: clusters in columns (top) show greater state dynamics than clusters in rows (left). P-values for (B) and (C) are shown in Additional file 2: Table S6B (one-sided Wilcoxon tests). (D) Browser view of chromatin state changes and RNA-seq profiles at the PPARG locus during differentiation; the red boxed area is enlarged (zoom, right).Back to article page