Figure 1

Rhesus and mouse DNA methylation levels detected on the human array are highly correlated. Scatter plots of rhesus (A-B) and mouse (C) methylation data (5-mC) generated from technical replicates run on the HumanMethylation450 BeadChips are shown for exact match (A; N = 35,901) and mismatch (B; N = 154,030) rhesus-competent probes, or mismatch mouse-competent probes (C; N = 9,734). D) Scatter plot of the 5-mC levels of the rhesus-competent probes compared to the levels found in humans. Each probe is represented as a colored dot that are mostly light blue but become dark blue, green, yellow, or red as the density of loci increases. For all plots, the diagonal red line indicates the regression line and the x and y-axes indicate the methylation level for each replicate (A-C) or the median methylation values of the samples for each species (D).