Figure 1

Pathway alterations in tri- and tetrasomic cell lines. A. 2-dimensional pathway analysis comparison of HCT116 with tetrasomy of chromosome 5 and DLD1 with trisomy of chromosome 13. Each dot represents an annotation as defined by GO and KEGG databases, color-coding marks related annotations as stated in the inset legend. The label “Others” indicates annotations that were not generalized in larger categories (see Methods). Examples of specific pathways categorized by the color- code are annotated. B. 2-dimensional pathway analysis comparison of HE35 (clone 2) with trisomy of chromosome 8 and RPE* with trisomy of chromosome 21. Asterisks indicate the cell lines with H2B-GFP.