High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells

Table 1 REACTOME and KEGG pathways enriched with candidate FH-synthetic lethal genes

Pathway	Genes	p-value
REACTOME_GABA_B_RECEPTOR_ACTIVATION	ADCY3, ADCY6, ADCY7, ADCY9, GNG3, KCNJ4, GNG4	0.0001
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	BMPR1B, CCL22, CSF3, CXCR6, EGF, GH1, IL1RAP, IL22, INHBB, LTA, TNFRSF10D, TNFRSF11A, TNFRSF1B, TNFSF13B, TNFSF8, EDA2R, TNFSF15	0.0024
REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA	GNG13, GNG3, PIK3CG, GNG4	0.0035
KEGG_APOPTOSIS	BCL2L1, CASP6, IL1RAP, IRAK1, MAP3K14, PIK3CG, PRKX, TNFRSF10D	0.0072
REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION	ARF1, DNM2, OSBPL1A, CTSC, KIF20A	0.0303
KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	FECH, HMOX2, UGT1A3, UGT2A3	0.0432
REACTOME_METABOLISM_OF_CARBOHYDRATES	ABCC5, B4GALT3, ENO3, KERA, PC, PKLR, PYGM, SLC2A1, BCAN, NUP205, SLC25A12, TALDO1	0.0453

ISSN: 1471-2164