Figure 2

GC correction of HCC1143 sample’s RC profile. GC correction results over the HCC1143 sample’s RC profile. (Left) Density plot of the normalized RC profiles. The density of the seqnorm-corrected profile distinguishes better the different copy numbers in the mixture. (Right) Read counts depending on the window’s GC content, with greater density as darker grey. In blue, regression line estimated through the typical approach. In orange, regression line estimated by seqnorm.