Figure 1

Flow chart describing the entire work flow. Integrated data analysis was performed on three genome wide datasets to identify overlapping 108 AD putative candidate genes which were ranked by using cumulative rank based scoring method. These genes were further used to create a PPI and identify overlapping proteins among 108 and proteins from CSF and plasma proteome. PPI was then used to create a layered network based on the subcellular localization information of 640 genes, to identify clusters using MCL algorithm and to retrieve functional annotation using DAVID web tool.