An overlapping set of genes is regulated by both NFIB and the glucocorticoid receptor during lung maturation

BMC Genomics

Table 2 Association of TF motifs with Nfib targets

*Motif*	*Gene*	FC	p _{a c t}	p _{r e p}	MAS
NFIA_full	Nfia	2.27	<10^-5	0.31	5.50
NFIB_full	Nfib	*2.75	<10^-5	0.27	5.12
NFIX_full	Nfix	-	<10^-4	0.26	4.67
Meis3_DBD_2	Meis3	NA	<10^-4	0.44	4.13
MEIS3_DBD_2	Meis3	NA	<10^-4	0.44	4.03
Meis2_DBD_2	Meis2	1.57	0.0001	0.53	3.98
SNAI2_DBD	Snai2	1.72	0.0002	0.86	3.78
Rxra_DBD	Rxra	-	0.0004	0.54	3.49
EBF1_full	Ebf1	-	0.0004	0.46	3.49
Rxrb_DBD	Rxrb	NA	0.0004	0.69	3.49
NR2F6_DBD_2	Nr2f6	-	0.0004	0.75	3.46
RXRA_DBD	Rxra	-	0.0006	0.62	3.22
NR2F1_DBD	Nr2f1	1.83	0.0007	0.74	3.18
RXRB_DBD	Rxrb	NA	0.0007	0.41	3.16
Pknox2_DBD	Pknox2	-	0.0009	0.41	3.05
TFAP4_full	Tfap4	NA	0.0010	0.24	3.02
PKNOX2_DBD	Pknox2	-	0.0010	0.60	3.00
RXRG_DBD	Rxrg	NA	0.0011	0.49	2.96
NR2C2_DBD	Nr2c2	-	0.0012	0.65	2.93
Nfib_MEME	Nfib	*2.75	0.0012	0.34	2.92

The table shows the TF motif name (motif), associated gene name (gene), expression fold-change (FC) of the gene, the (unadjusted) motif enrichment p-value in the activated set of genes (p_{a
c
t}), the (unadjusted) motif enrichment p-value in the repressed set of genes (p_{r
e
p}), and the motif association score (MAS). Rank is based on the magnitude of the MAS, “NA” indicates that no expression data is available for the TF gene and “-” in the FC column indicates that expression change is not significant (p-value >0.05). Motif names all in uppercase are derived from human TFs, others are from mouse TFs. *Although Nfib expression increases in the Nfib-KO, no functional protein is produced.

ISSN: 1471-2164