Figure 1
From: Inference of high resolution HLA types using genome-wide RNA or DNA sequencing reads
PHLAT algorithm workflow. The algorithm consists of read mapping via Bowtie 2 to a reference sequence comprising the human genome and a plurality of genomic sequences of HLA alleles (I), selection of candidate alleles based on the number of mapped reads (II-IV), and log-likelihood scoring (V) over every pair of selected candidate alleles (e.g. a pair of a and b alleles). The pair of alleles with the best likelihood score is reported as the inferred HLA type at a given locus.